Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

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Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

Strom, Nora I. (författare): Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden; Department of Biomedicine, Aarhus University, Aarhus, Denmark

Smit, Dirk J. A. (författare): Department of Psychiatry, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, The Netherlands

Silzer, Talisa (författare): Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada

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Iyegbe, Conrad (författare): Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England; Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, USA

Burton, Christie L. (författare): Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada

Pool, René (författare): Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands

Lemire, Mathieu (författare): Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada

Crowley, James J. (författare): Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Region Stockholm, Sweden; Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, USA

Hottenga, Jouke-Jan (författare): Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands

Ivanov, Volen Z. (författare): Karolinska Institutet

Larsson, Henrik, 1975- (författare): Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Lichtenstein, Paul (författare): Karolinska Institutet

Magnusson, Patrik (författare): Karolinska Institutet

Rück, Christian (författare): Karolinska Institutet

Schachar, Russell J. (författare): Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada

Wu, Hei Man (författare): Department of Genetics and Genomic Sciences, Icahn School of Medicine, Mount Sinai, New York, USA

Meier, Sandra M. (författare): Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Community Health & Epidemiology, Dalhousie University, NS, Dalhousie, Canada

Crosbie, Jennifer (författare): Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada

Arnold, Paul D. (författare): The Mathison Centre for Mental Health Research & Education, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada; Departments of Psychiatry and Medical Genetics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Mattheisen, Manuel (författare): Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Department of Psychiatry, Dalhousie University, Halifax, NS, Canada; Community Health & Epidemiology, Dalhousie University, NS, Dalhousie, Canada

Boomsma, Dorret I. (författare): Netherlands Twin Register, Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands

Mataix-Cols, David (författare): Karolinska Institutet

Cath, Danielle (författare): Rijksuniversiteit Groningen and Department of Psychiatry, University Medical Center Groningen, Groningen, Netherlands; Department of specialized training, Drenthe Mental Health Care Institute, Assen, The Netherlands

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2022-11-15
2022
Engelska.
Ingår i: Translational Psychiatry. - : Springer Nature. - 2158-3188. ; 12:1

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

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Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies suggest that it is moderately heritable. In this study, we pooled phenotypic and genomic data from seven international cohorts (N = 27,537 individuals) and conducted a genome wide association study (GWAS) meta-analysis of parent- or self-reported hoarding symptoms (HS). We followed up the results with gene-based and gene-set analyses, as well as leave-one-out HS polygenic risk score (PRS) analyses. To examine a possible genetic association between hoarding symptoms and other phenotypes we conducted cross-trait PRS analyses. Though we did not report any genome-wide significant SNPs, we report heritability estimates for the twin-cohorts between 26-48%, and a SNP-heritability of 11% for an unrelated sub-cohort. Cross-trait PRS analyses showed that the genetic risk for schizophrenia and autism spectrum disorder were significantly associated with hoarding symptoms. We also found suggestive evidence for an association with educational attainment. There were no significant associations with other phenotypes previously linked to HD, such as obsessive-compulsive disorder, depression, anxiety, or attention-deficit hyperactivity disorder. To conclude, we found that HS are heritable, confirming and extending previous twin studies but we had limited power to detect any genome-wide significant loci. Much larger samples will be needed to further extend these findings and reach a "gene discovery zone". To move the field forward, future research should not only include genetic analyses of quantitative hoarding traits in larger samples, but also in samples of individuals meeting strict diagnostic criteria for HD, and more ethnically diverse samples.

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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Av lärosätet: Örebro universitet; Karolinska Institutet

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Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals

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