Autism spectrum disorders and underlying brain pathology in CHARGE association.

• The rate of autism spectrum disorders (ASDs) and brain abnormalities was analyzed in 31 individuals (15 males, 16 females; age range 1mo to 31y, mean age 8y 11mo) with CHARGE association, as part of a multidisciplinary study. A meticulous neuropsychiatric examination was performed, including standardized autism diagnostic interviews. Judgement regarding ASDs was impossible in three infants and three patients who were deaf and blind. Five individuals met diagnostic criteria for autism, five for an autistic-like condition, and seven for autistic traits. Brain abnormalities were indicated in almost three-quarters of examined individuals, and midline abnormalities of the forebrain in one-third. Awareness of the coexistence of CHARGE and ASDs is important in habilitation care in CHARGE. Moreover, the results indicate that a subgroup of ASDs may be associated with errors in early embryonic brain development.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Abnormalities

Multiple

pathology

Adolescent

Adult

Autistic Disorder

classification

pathology

Autonomic Nervous System Diseases

pathology

Brain

abnormalities

pathology

Child

Child Behavior Disorders

pathology

Child

Preschool

Cognition

Coloboma

pathology

Craniofacial Abnormalities

pathology

Female

Hearing Loss

pathology

Heart Defects

Congenital

pathology

Humans

Infant

Infant

Newborn

Magnetic Resonance Imaging

Male

Neuropsychological Tests

Pregnancy

Pregnancy Complications

pathology

Tomography

X-Ray Computed

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