Father's environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study

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Father's environment before conception and asthma risk in his children: a multi-generation analysis of the Respiratory Health In Northern Europe study

Svanes, C. (författare): Centre for International Health, University of Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Norway

Koplin, J. (författare): Centre for International Health, University of Bergen, Norway; School of Population and Global Health, University of Melbourne, Australia; Murdoch Childrens Research Institute, Melbourne, Australia

Skulstad, S. M. (författare): Department of Clinical Science, University of Bergen, Norway; Department of Obstetrics, Oslo University Hospital, Rikshospitalet, Oslo, Norway

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Johannessen, A. (författare): Department of Clinical Science, University of Bergen, Norway; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway

Jögi, Rain (författare): Uppsala universitet,Lung- allergi- och sömnforskning,Lung Clinic, Foundation Tartu University Clinics, Tartu, Estonia; Department of Pulmonary Medicine, Tartu University, Estonia

Benediktsdottir, B. (författare): Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland; University of Iceland, Medical Faculty

Bråbäck, Lennart (författare): Umeå universitet,Yrkes- och miljömedicin,Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Sweden

Carsin, A. E. (författare): Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain

Dharmage, S. (författare): Department of Clinical Science, University of Bergen, Norway; School of Population and Global Health, University of Melbourne, Australia

Dratva, J. (författare): Centre for International Health, University of Bergen, Norway; Department of Epidemiology and Public Health, Gender & Health, Swiss Tropical and Public Health Institute, Basel University, Switzerland

Forsberg, Bertil (författare): Umeå universitet,Yrkes- och miljömedicin,Arcum,Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umeå University, Sweden

Gislason, T. (författare): Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland; University of Iceland, Medical Faculty

Heinrich, J. (författare): Institute of Epidemiology I, Helmholtz Zentrum, Munich, Germany

Holm, Mathias, 1969 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden

Janson, Christer (författare): Uppsala universitet,Lung- allergi- och sömnforskning

Jarvis, D. (författare): Faculty of Medicine, National Heart & Lung Institute, Imperial College, London, UK

Jogi, R. (författare)

Krauss-Etschmann, S. (författare): Research Center Borstel, Leibniz- Center for Medicine and Biosciences, Divison of Experimental Asthma Research, University of Kiel, Germany

Lindberg, Eva (författare): Uppsala universitet,Lung- allergi- och sömnforskning

Macsali, F. (författare): Department of Obstetrics and Gynecology, Haukeland, University Hospital, Bergen, Norway and

Malinovschi, Andrei, 1978- (författare): Uppsala universitet,Klinisk fysiologi

Modig, Lars (författare): Umeå universitet,Yrkes- och miljömedicin,Centre for International Health, University of Bergen, Norway,Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine, Umea ̊ University, Sweden

Norbäck, Dan (författare): Uppsala universitet,Arbets- och miljömedicin

Omenaas, E. (författare): Department of Clinical Science, University of Bergen, Norway; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway

Saure, E. W. (författare): Department of Clinical Science, University of Bergen, Norway

Sigsgaard, T. (författare): Department of Public Health, Aarhus University, Denmark

Skorge, T. D. (författare): Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway

Svanes, O. (författare)

Torén, Kjell, 1952 (författare): Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin,Institute of Medicine, Department of Public Health and Community Medicine, Section of Occupational and environmental medicine,Occupational and Environmental Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden

Torres, C. (författare): Department of Clinical Science, University of Bergen, Norway

Schlunssen, V. (författare): Department of Public Health; Aarhus University, Denmark

Real, F. G. (författare): Department of Clinical Science, University of Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland, University Hospital, Bergen, Norway

Svanes, Øistein (författare): Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Norway

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(creator_code:org_t)

2016-08-25
2017
Engelska.
Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 46:1, s. 235-245

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Background: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests that paternal environment before conception also impacts child health. We aimed to investigate the association between children's asthma risk and parental smoking and welding exposures prior to conception. Methods: In a longitudinal, multi-country study, parents of 24 168 offspring aged 2-51 years provided information on their life-course smoking habits, occupational exposure to welding and metal fumes, and offspring's asthma before/after age 10 years and hay fever. Logistic regressions investigated the relevant associations controlled for age, study centre, parental characteristics (age, asthma, education) and clustering by family. Results: Non-allergic early-onset asthma (asthma without hay fever, present in 5.8%) was more common in the offspring with fathers who smoked before conception {odds ratio [OR] = 1.68 [95% confidence interval (CI) = 1.18-2.41]}, whereas mothers' smoking before conception did not predict offspring asthma. The risk was highest if father started smoking before age 15 years [3.24 (1.67-6.27)], even if he stopped more than 5 years before conception [2.68 (1.17-6.13)]. Fathers' pre-conception welding was independently associated with non-allergic asthma in his offspring [1.80 (1.29-2.50)]. There was no effect if the father started welding or smoking after birth. The associations were consistent across countries. Conclusions: Environmental exposures in young men appear to influence the respiratory health of their offspring born many years later. Influences during susceptible stages of spermatocyte development might be important and needs further investigation in humans. We hypothesize that protecting young men from harmful exposures may lead to improved respiratory health in future generations.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)

Nyckelord

asthma
epidemiology
smoking
occupational exposure
epigenesis
grandmaternal smoking patterns
sperm microrna content
slow growth
period
transgenerational responses
cigarette-smoking
tobacco-smoke
childhood asthma
germ-line
follow-up
exposure
Public
Environmental & Occupational Health
asthma

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Arbetsmedicin oc ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin

Artiklar i publikationen: International Jo ...

Av lärosätet: Göteborgs universitet; Umeå universitet; Uppsala universitet

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