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WFRF:(Sudic Dzana Hukic)
 

Sökning: WFRF:(Sudic Dzana Hukic) > Tidskriftsartikel > Cognitive Manic Sym...

  • Hukic, Dzana SudicKarolinska Institutet (författare)

Cognitive Manic Symptoms in Bipolar Disorder Associated with Polymorphisms in the DAOA and COMT Genes

  • Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

  • 2013-07-05
  • Public Library of Science (PLoS),2013

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/273251
  • https://gup.ub.gu.se/publication/273251URI
  • https://doi.org/10.1371/journal.pone.0067450DOI
  • https://lup.lub.lu.se/record/3975811URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:126955008URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction:Bipolar disorder is characterized by severe mood symptoms including major depressive and manic episodes. During manic episodes, many patients show cognitive dysfunction. Dopamine and glutamate are important for cognitive processing, thus the COMT and DAOA genes that modulate the expression of these neurotransmitters are of interest for studies of cognitive function.Methodology:Focusing on the most severe episode of mania, a factor was found with the combined symptoms of talkativeness, distractibility, and thought disorder, considered a cognitive manic symptoms (CMS) factor. 488 patients were genotyped, out of which 373 (76%) had talkativeness, 269 (55%) distractibility, and 372 (76%) thought disorder. 215 (44%) patients were positive for all three symptoms, thus showing CMS (Table 1). As population controls, 1,044 anonymous blood donors (ABD) were used. Case-case and case-control design models were used to investigate genetic associations between cognitive manic symptoms in bipolar 1 disorder and SNPs in the COMT and DAOA genes. Results: The finding of this study was that cognitive manic symptoms in patients with bipolar 1 disorder was associated with genetic variants in the DAOA and COMT genes. Nominal association for DAOA SNPs and COMT SNPs to cognitive symptoms factor in bipolar 1 disorder was found in both allelic (Table 2) and haplotypic (Table 3) analyses. Genotypic association analyses also supported our findings. However, only one association, when CMS patients were compared to ABD controls, survived correction for multiple testing by max (T) permutation. Data also suggested interaction between SNPs rs2391191 in DAOA and rs5993883 in COMT in the case-control model. Conclusion:Identifying genes associated with cognitive functioning has clinical implications for assessment of prognosis and progression. Our finding are consistent with other studies showing genetic associations between the COMT and DAOA genes and impaired cognition both in psychiatric disorders and in the general population. © 2013 Hukic et al.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Frisén, LouiseKarolinska Institutet (författare)
  • Backlund, LenaKarolinska Institutet (författare)
  • Lavebratt, CatharinaKarolinska Institutet (författare)
  • Landén, Mikael,1966Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology(Swepub:gu)xlandt (författare)
  • Träskman Bendz, LilLund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)psyk-lt8 (författare)
  • Edman, GunnarKarolinska Institutet (författare)
  • Schalling, MartinKarolinska Institutet (författare)
  • Ösby, UrbanKarolinska Institutet (författare)
  • Karolinska InstitutetInstitutionen för neurovetenskap och fysiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:PLoS ONE: Public Library of Science (PLoS)81932-6203

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  • PLoS ONE (Sök värdpublikationen i LIBRIS)

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