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- Isacsson, G.Department of Orofacial Pain and Jaw Function, Västmanland County Hospital, Västerås, Sweden,Vastmanland Cty Hosp, Dept Orofacial Pain & Jaw Funct, Vasteras, Sweden (författare)
Pain relief following a single-dose intra-articular injection of methylprednisolone in the temporomandibular joint arthralgia-A multicentre randomised controlled trial
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
- 2018-10-10
- Wiley,2019
Nummerbeteckningar
- LIBRIS-ID:oai:gup.ub.gu.se/276586
- https://gup.ub.gu.se/publication/276586URI
- https://doi.org/10.1111/joor.12718DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-7006URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372872URI
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- Språk:engelska
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Anmärkningar
- Background Temporomandibular joint (TMJ) arthralgia is a painful condition assumed to be associated with local inflammation. Objective The objective of the present study was to determine the efficacy for reducing pain of a single-dose intra-articular (IA) injection of methylprednisolone to the TMJ. The hypothesis was that methylprednisolone would effectively reduce TMJ pain. Methods This randomised, double-blind, parallel-group, multicentre, controlled study included visits for enrolment, treatment and 4-week follow-up. The study included patients 18 years and older who had been diagnosed with unilateral TMJ arthralgia. All participants were randomly assigned to receive 1 mL IA injections of methylprednisolone or saline. The primary outcome was change in recorded pain intensity on a visual analogue scale (VAS) at maximum jaw opening, analysed in the per protocol population. Results In total, 54 patients were randomly assigned to single-dose IA injections with methylprednisolone (n = 27) or saline (n = 27). Between baseline and the 4-week follow-up, VAS-rated pain intensity at maximum jaw opening decreased from a mean of 61.0 (95% confidence interval [CI]: 50.1; 70.7) to 33.9 (95% CI: 21.6; 46.2) in the methylprednisolone group and from 59.6 (95% CI: 50.7; 65.9) to 33.9 (95% CI: 23.8; 43.9) in the saline group. The between-group difference was not significant (P = 0.812). Treatment-related adverse events were doubled in the methylprednisolone group. Conclusion Methylprednisolone provided no additional benefit for reducing pain, but caused more harm compared with saline following a single-dose IA injection in patients with TMJ arthralgia.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Odontologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Dentistry hsv//eng
- arthralgia
- corticosteroids
- injection
- intra-articular
- pain management
- temporomandibular joint
- clinical importance
- depression
- validity
- Dentistry
- Oral Surgery & Medicine
- arthralgia
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Schumann, M.Department of Orofacial Pain and Jaw Function, Västmanland County Hospital, Västerås, Sweden,Vastmanland Cty Hosp, Dept Orofacial Pain & Jaw Funct, Vasteras, Sweden (författare)
- Nohlert, Eva,1955-Uppsala universitet,Centrum för klinisk forskning, Västerås(Swepub:uu)evnoh132 (författare)
- Mejersjö, ChristinaGothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology,Clinic of Orofacial Pain, Sahlgrenska Academy and Public Dental Health, Gothenburg, Sweden(Swepub:gu)xmejch (författare)
- Tegelberg, ÅkeMalmö universitet,Odontologiska fakulteten (OD),Department of Orofacial Pain and Jaw Function, Postgraduate Dental Education Center, Örebro, Sweden,Postgrad Dent Educ Ctr, Dept Orofacial Pain & Jaw Funct, Orebro, Sweden;Malmo Univ, Fac Odontol, Dept Orofacial Pain & Jaw Funct, Malmo, Sweden(Swepub:mau)odakte (författare)
- Department of Orofacial Pain and Jaw Function, Västmanland County Hospital, Västerås, SwedenVastmanland Cty Hosp, Dept Orofacial Pain & Jaw Funct, Vasteras, Sweden (creator_code:org_t)
Sammanhörande titlar
- Ingår i:J Oral Rehabil: Wiley46:1, s. 5-130305-182X1365-2842
- Ingår i:Journal of Oral Rehabilitation: Wiley46:1, s. 5-131365-2842
Internetlänk
- https://doi.org/10.1111/joor.12718
- https://doi.org/10.1111/joor.12718Fulltext
- https://mau.diva-portal.org/smash/get/diva2:1403960/FULLTEXT01.pdffulltext:print
- https://uu.diva-portal.org/smash/get/diva2:1277293/FULLTEXT01.pdffulltext:print
- https://gup.ub.gu.se/publication/276586
- https://doi.org/10.1111/joor.12718
- https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-7006
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-372872
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