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High prevalence of ...
High prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis
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- Olsson, Rolf (författare)
- Sahlgrens University Hospital
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- Glaumann, Hans (författare)
- Karolinska University Hospital
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- Almer, Sven (författare)
- Östergötlands Läns Landsting,Linköpings universitet,Gastroenterologi och hepatologi,Hälsouniversitetet,Endokrin- och magtarmmedicinska kliniken US
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- Broome, Ulrika (författare)
- Karolinska University Hospital
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- Lebrun, Barbro (författare)
- Karolinska University Hospital
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- Bergquist, Annika (författare)
- Karolinska Institutet,Karolinska University Hospital
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- Bjornsson, Einar (författare)
- Sahlgrens University Hospital
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- Prytz, Hanne (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Hospital
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- Danielsson, Åke (författare)
- Umeå universitet,Medicin,Umeå University Hospital
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- Lindgren, Stefan (författare)
- Malmö University
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- Engelska.
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Ingår i: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - : Elsevier BV. - 0953-6205 .- 1879-0828. ; 20:2, s. 190-196
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Overlap syndrome is a term used for overlapping features of autoimmune hepatitis and primary sclerosing cholangitis or primary biliary cirrhosis and for autoimmune cholangitis. We describe a high prevalence of small duct primary sclerosing cholangitis among patients with overlapping autoimmune hepatitis and primary sclerosing cholangitis. Methods: We sought to retrieve all patients with overlap syndrome between primary sclerosing cholangitis and autoimmune hepatitis in six university hospitals in Sweden. The revised autoimmune hepatitis scoring system proposed by the International Autoimmune Hepatitis Group was used to establish the diagnosis autoimmune hepatitis. Endoscopic retrograde cholangiography and/or magnetic resonance cholangiography were used to separate the primary sclerosing cholangitis cases diagnosed through liver biopsy into small and large primary sclerosing cholangitis. A histologocial diagnosis compatible with both autoimmune hepatitis and primary sclerosing cholangitis was required for inclusion. Results: 26 patients fulfilled our criteria for histological overlap of autoimmune hepatitis and primary sclerosing cholangitis, 7 (27%) of which had small duct primary sclerosing cholangitis. The reliability of the diagnosis small duct primary sclerosing cholangitis was supported by a very close similarity between small and large duct primary sclerosing cholangitis patients in clinical and laboratory data, and by a poor response to immunosuppressive therapy in the small duct primary sclerosing cholangitis patients. Patients with large duct overlap syndrome had a good response to immunosuppressive therapy. In both groups, our limited experience from ursodeoxycholic acid was largely poor. Conclusions: Small duct primary sclerosing cholangitis is prevalent in the overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
Nyckelord
- Overlap syndrome
- PSC
- Small duct PSC
- Autoimmune hepatitis
- Immunosuppression
- Ursodeoxycholic acid
- MEDICINE
- MEDICIN
- Immunosuppression
- Autoimmune hepatitis
- Small duct PSC
- Overlap syndrome
- PSC
- Ursodeoxycholic acid
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Olsson, Rolf
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Glaumann, Hans
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Almer, Sven
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Broome, Ulrika
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Lebrun, Barbro
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Bergquist, Annik ...
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visa fler...
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Bjornsson, Einar
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Prytz, Hanne
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Danielsson, Åke
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Lindgren, Stefan
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Allmänmedicin
- Artiklar i publikationen
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EUROPEAN JOURNAL ...
- Av lärosätet
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Linköpings universitet
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Umeå universitet
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Lunds universitet
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Karolinska Institutet