Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis

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Identification of Sarcopenia Components That Discriminate Slow Walking Speed: A Pooled Data Analysis

Manini, T. M. (författare): Univ Florida, Dept Aging & Geriatr Res, 2004 Mowry Rd, Gainesville, FL 32611 USA.,Florida Museum Natural History

Patel, S. M. (författare): Calif Pacific Med Res Inst, San Francisco, CA USA.,California Pacific Medical Center

Newman, A. B. (författare): Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA 15261 USA.,University of Pittsburgh

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Travison, T. G. (författare): Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Hebrew SeniorLife, Hinda & Arthur Marcus Inst Aging Res, Boston, MA USA.,Harvard Medical School

Kiel, D. P. (författare): Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Hebrew SeniorLife, Hinda & Arthur Marcus Inst Aging Res, Boston, MA USA.,Harvard Medical School

Mellström, Dan, 1945 (författare): Gothenburg University,Göteborgs universitet,University of Gothenburg,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Pencina, K. M. (författare): Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Hebrew SeniorLife, Hinda & Arthur Marcus Inst Aging Res, Boston, MA USA.,Harvard Medical School

Wilson, K. E. (författare): Hologic Inc, Marlborough, MA USA.

Kelly, T. L. (författare): Hologic Inc, Marlborough, MA USA.

Massaro, J. M. (författare): Boston Univ, Dept Biostat, Boston, MA 02215 USA.,Univ Maryland Baltimore, Dept Epidemiol, Baltimore, MD USA.,Univ N Carolina, Sch Med, Chapel Hill, NC 27515 USA.,Boston University,University of Maryland, Baltimore,University of North Carolina

Fielding, R. A. (författare): Tufts Univ, Boston, MA 02111 USA.,Tufts University

Magaziner, J. (författare)

Correa-de-Araujo, R. (författare): Calif Pacific Med Res Inst, San Francisco, CA USA.;NIA, Div Geriatr & Clin Gerontol, US Dept HHS, NIH, Bethesda, MD 20892 USA.,National Institute on Aging, United States,National Institutes of Health, United States

Kwok, T. C. Y. (författare): Chinese Univ, Hong Kong, Peoples R China.,Chinese University of Hong Kong

Hirani, V. (författare): Univ Sydney, Sydney, NSW, Australia.,University of Sydney

Karlsson, Magnus K. (författare): Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups

D'Agostino, R. B. (författare): Boston Univ, Boston, MA 02215 USA.,Boston University

Mellström, Dan, 1945 (författare): Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition

Ohlsson, Claes, 1965 (författare): University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Univ Gothenburg, Gothenburg, Sweden.

Ribom, Eva L (författare): Uppsala University,Uppsala universitet,Ortopedi

Jordan, J. M. (författare)

Bhasin, S. (författare): Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Hebrew SeniorLife, Hinda & Arthur Marcus Inst Aging Res, Boston, MA USA.,Harvard Medical School

Cawthon, P. M. (författare): Calif Pacific Med Res Inst, San Francisco, CA USA.

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Univ Florida, Dept Aging & Geriatr Res, 2004 Mowry Rd, Gainesville, FL 32611 USA Florida Museum Natural History (creator_code:org_t)

2020-07-07
2020
Engelska.
Ingår i: Journal of the American Geriatrics Society. - : Wiley. - 0002-8614 .- 1532-5415. ; 68:7, s. 1419-1428

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Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

BACKGROUND The Sarcopenia Definitions and Outcomes Consortium (SDOC) sought to identify cut points for muscle strength and body composition measures derived from dual-energy x-ray absorptiometry (DXA) that discriminate older adults with slow walking speed. This article presents the core analyses used to guide the SDOC position statements. DESIGN Cross-sectional data analyses of pooled data. SETTING University-based research assessment centers. PARTICIPANTS Community-dwelling men (n = 13,652) and women: (n = 5,115) with information on lean mass by DXA, grip strength (GR), and walking speed. MEASUREMENTS Thirty-five candidate sarcopenia variables were entered into sex-stratified classification and regression tree (CART) models to agnostically choose variables and cut points that discriminate slow walkers (<0.80 m/s). Models with alternative walking speed outcomes were also evaluated (<0.60 and <1.0 m/s and walking speed treated continuously). RESULTS CART models identified GR/body mass index (GRBMI) and GR/total body fat (GRTBF) as the primary discriminating variables for slowness in men and women, respectively. Men with GRBMI of 1.05 kg/kg/m(2)or less were approximately four times more likely to be slow walkers than those with GRBMI of greater than 1.05 kg/kg/m(2). Women with GRTBF of less than 0.65 kg/kg were twice as likely to be slow walkers than women with GRTBF of 0.65 kg/kg or greater. Models with alternative walking speed outcomes selected only functions of GR as primary discriminators of slowness in both men and women. DXA-derived lean mass measures did not consistently discriminate slow walkers. CONCLUSION GR with and without adjustments for body size and composition consistently discriminated older adults with slowness. CART models did not select DXA-based lean mass as a primary discriminator of slowness. These results were presented to an SDOC Consensus Panel, who used them and other information to develop the SDOC Position Statements.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)

Nyckelord

disability
dynapenia
weakness
gait speed
physical performance
cut points
health
muscle
definition
disability
diagnosis
mobility
Geriatrics & Gerontology
disability

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Geriatrik

Artiklar i publikationen: Journal of the A ...

Av lärosätet: Göteborgs universitet; Uppsala universitet; Lunds universitet

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