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The Amyloid-beta Pa...
The Amyloid-beta Pathway in Alzheimer's Disease
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- Hampel, H. (author)
- Eisai Inc, Neurol Business Grp, Woodcliff Lake, NJ 07677 USA.
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- Hardy, J. (author)
- UCL, UK Dementia Res Inst, London, England.;UCL, Dept Neurodegenerat Dis, UCL Inst Neurol, London, England.
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrens Univ Hosp, Clin Neurochem Lab, Mölndal, Sweden.;Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Inst Neurosci & Physiol, Mölndal, Sweden.
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- Chen, C. (author)
- Natl Univ Singapore, Memory Aging & Cognit Ctr, Yong Loo Lin Sch Med, Dept Pharmacol, Singapore, Singapore.;Natl Univ Singapore, Memory Aging & Cognit Ctr, Yong Loo Lin Sch Med, Dept Psychol Med, Singapore, Singapore.
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- Perry, G. (author)
- Univ Texas San Antonio, Dept Biol, San Antonio, TX USA.;Univ Texas San Antonio, Inst Neurosci, San Antonio, TX USA.
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- Kim, S. H. (author)
- Hanyang Univ, Coll Med, Dept Neurol, Seoul, South Korea.;Hanyang Univ Hosp, Cell Therapy Ctr, Seoul, South Korea.
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik,BioArct AB, Stockholm, Sweden.,Univ Nevada Las Vegas, Sch Integrated Hlth Sci, Dept Brain Hlth, Chambers Grundy Ctr Transformat Neurosci, Las Vegas, NV USA.
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- Aisen, P. (author)
- USC Alzheimers Therapeut Res Inst, San Diego, CA USA.
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- Vendruscolo, M. (author)
- Univ Cambridge, Ctr Misfolding Dis, Dept Chem, Cambridge, England.
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- Iwatsubo, T. (author)
- Univ Tokyo, Grad Sch Med, Dept Neuropathol, Tokyo, Japan.
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- Masters, C. L. (author)
- Florey Inst, Dementia Res, Parkville, Vic, Australia.;Univ Melbourne, Parkville, Vic, Australia.
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- Cho, M. (author)
- Eisai Inc, Neurol Business Grp, Woodcliff Lake, NJ 07677 USA.
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Lannfelt, L. (author)
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Cummings, J. L. (author)
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- Vergallo, A. (author)
- Eisai Inc, Neurol Business Grp, Woodcliff Lake, NJ 07677 USA.
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Eisai Inc, Neurol Business Grp, Woodcliff Lake, NJ 07677 USA UCL, UK Dementia Res Inst, London, England.;UCL, Dept Neurodegenerat Dis, UCL Inst Neurol, London, England. (creator_code:org_t)
- 2021-08-30
- 2021
- English.
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26, s. 5481-5503
- Related links:
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https://www.nature.c...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Breakthroughs in molecular medicine have positioned the amyloid-beta (A beta) pathway at the center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics leading to synaptic failure, neurodegeneration, and clinical onset are still under intense investigation, the established biochemical alterations of the A beta cycle remain the core biological hallmark of AD and are promising targets for the development of disease-modifying therapies. Here, we systematically review and update the vast state-of-the-art literature of A beta science with evidence from basic research studies to human genetic and multi-modal biomarker investigations, which supports a crucial role of A beta pathway dyshomeostasis in AD pathophysiological dynamics. We discuss the evidence highlighting a differentiated interaction of distinct A beta species with other AD-related biological mechanisms, such as tau-mediated, neuroimmune and inflammatory changes, as well as a neurochemical imbalance. Through the lens of the latest development of multimodal in vivo biomarkers of AD, this cross-disciplinary review examines the compelling hypothesis- and data-driven rationale for A beta-targeting therapeutic strategies in development for the early treatment of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- basal forebrain atrophy
- apolipoprotein-e genotype
- blood-brain-barrier
- density-lipoprotein receptor
- impair synaptic plasticity
- gamma-secretase activity
- genome-wide association
- precursor protein
- gene
- a-beta
- cerebrospinal-fluid
- Biochemistry & Molecular Biology
- Neurosciences & Neurology
- Psychiatry
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Hampel, H.
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Hardy, J.
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Blennow, Kaj, 19 ...
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Chen, C.
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Perry, G.
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Kim, S. H.
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show more...
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Lannfelt, Lars
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Aisen, P.
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Vendruscolo, M.
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Iwatsubo, T.
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Masters, C. L.
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Cho, M.
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Lannfelt, L.
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Cummings, J. L.
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Vergallo, A.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Molecular Psychi ...
- By the university
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University of Gothenburg
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Uppsala University