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Sökning: WFRF:(Fristrup C) > Aspirin as secondar...

Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial

Yaqub, S. (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway. shya@ous-hf.no; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
Bjornbeth, B. A. (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.
Angelsen, J. H. (författare)
Department of Acute and Digestive Surgery, Haukeland University Hospital, Bergen, Norway; Departments of Clinical Medicine, University of Bergen, Bergen, Norway,Haukeland Hosp, Dept Acute & Digest Surg, Bergen, Norway.;Univ Bergen, Dept Clin Med, Bergen, Norway.
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Fristrup, C. W. (författare)
Department of Surgery, Odense University Hospital, Odense C, Denmark,Odense Univ Hosp, Dept Surg, Odense C, Denmark.
Gronbech, J. E. (författare)
Department of Gastrointestinal Surgery, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway; Department of Clinical and Molecular Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway,Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Trondheim, Norway.;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, NTNU, Trondheim, Norway.
Hemmingsson, Oskar, 1975- (författare)
Umeå universitet,Kirurgi,Department of Surgical and Perioperative Sciences, Umeå University, Umea, Sweden,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden.
Isaksson, Bengt (författare)
Uppsala universitet,Gastrointestinalkirurgi
Juel, I. S. (författare)
Department of Gastrointestinal Surgery, St. Olav’s Hospital, Trondheim University Hospital, Trondheim, Norway,Univ Trondheim Hosp, St Olavs Hosp, Dept Gastrointestinal Surg, Trondheim, Norway.
Larsen, P. N. (författare)
Department of Gastrointestinal Surgery, Rigshospitalet, Copenhagen, Denmark,Rigshosp, Dept Gastrointestinal Surg, Copenhagen, Denmark.
Lindell, G. (författare)
Department of Surgery, Skåne University Hospital, Lund, Sweden,Skane Univ Hosp, Dept Surg, Lund, Sweden.
Mortensen, F. V. (författare)
Department of Surgery, Aarhus University Hospital, Aarhus N, Denmark,Aarhus Univ Hosp, Dept Surg, Aarhus N, Denmark.
Mortensen, K. E. (författare)
Department of Gastrointestinal Surgery, University Hospital of North, Tromsø, Norway,Univ Hosp North, Dept Gastrointestinal Surg, Tromso, Norway.
Rizell, Magnus, 1963 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Transplantation, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Transplantat, Gothenburg, Sweden.
Sandström, Per A, 1965- (författare)
Linköpings universitet,Medicinska fakulteten,Avdelningen för kirurgi, ortopedi och onkologi,Region Östergötland, Kirurgiska kliniken US,Cty Council Ostergotland, Dept Surg, Linköping, Sweden.;Div Surg, Dept Biomed & Clin Sci Orthoped & Oncol, Linköping, Sweden.
Sandvik, O. M. (författare)
Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Dept Gastrointestinal Surg, Stavanger, Norway.
Sparrelid, E. (författare)
Karolinska Institutet
Taflin, Helena (författare)
Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg, Sweden,Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Clin Sci, Dept Surg, Gothenburg, Sweden.
Tasken, K. (författare)
Institute for Cancer Research, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Inst Canc Res, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
Brudvik, Kristoffer W. (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
Fretland, Åsmund A. (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
Horn, Arild (författare)
Department of Acute and Digestive Surgery, Haukeland University Hospital, Bergen, Norway; Departments of Clinical Medicine, University of Bergen, Bergen, Norway
Kleive, Dyre (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
Labori, Knut J. (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway
Søreide, Jon A. (författare)
Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway
Tholfsen, Tore (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
Villanger, Olaug (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
Waage, Anne (författare)
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway
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Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway shya@ous-hf.no; Institute of Clinical Medicine, University of Oslo, Oslo, Norway Oslo Univ Hosp, Dept Hepato Pancreato Biliary Surg, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway. (creator_code:org_t)
2021-09-20
2021
Engelska.
Ingår i: Trials. - London, United Kingdom : Springer Science and Business Media LLC. - 1745-6215. ; 22:1
Relaterad länk:
https://trialsjourna...
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https://doi.org/10.1...
https://umu.diva-por... (primary) (Raw object)
https://liu.diva-por... (primary) (Raw object)
https://uu.diva-port... (primary) (Raw object)
https://gup.ub.gu.se...
https://doi.org/10.1...
https://urn.kb.se/re...
https://urn.kb.se/re...
https://urn.kb.se/re...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled study to determine whether adjuvant treatment with low-dose aspirin (acetylsalicylic acid (ASA)) can improve disease-free survival in patients treated for colorectal cancer liver metastases (CRCLM). Up to 800 patients operated for CRCLM will be randomized to Arm#1 ASA 160 mg once daily or Arm#2 Placebo, for a period of 3 years or until disease recurrence. The patients will be recruited at all major hepatobiliary surgical units in Norway, Sweden and Denmark and have follow-up according to standard of care and the National Guidelines. Discussion The ASAC trial will be the first clinical interventional trial to assess the potential beneficial role of ASA in recurrence of CRCLM and survival. ASA is an inexpensive, well-tolerated and easily accessible drug that will be highly potential as adjuvant drug in secondary prevention of CRCLM if the study shows a beneficial effect. We will also determine the effect of ASA as adjuvant treatment on Health-Related Quality of Life and the cost-effectiveness.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Colorectal cancer
Liver metastases
Aspirin
Acetylsalicylic acid
Secondary prevention
regulatory t-cells
antitumor immune-responses
pik3ca mutation
follow-up
cyclooxygenase-2
suppression
inhibition
mortality
diagnosis
adenomas
Research & Experimental Medicine
Acetylsalicylic acid

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