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Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.

Kelsoe, John (author)
Ou, Anna (author)
Rosenthal, Sara (author)
show more...
Adli, Mazda (author)
Akiyama, Kazufumi (author)
Akula, Nirmala (author)
Alda, Martin (author)
Amare, Azmeraw T (author)
Ardau, Raffaella (author)
Arias, Bárbara (author)
Aubry, Jean-Michel (author)
Backlund, Lena (author)
Karolinska Institutet
Banzato, Claudio (author)
Bauer, Michael (author)
Baune, Bernhard (author)
Bellivier, Frank (author)
Benabarre, Antonio (author)
Bengesser, Susanne (author)
Abesh, Bhattacharjee (author)
Biernacka, Joanna (author)
Bui, Elise (author)
Cervantes, Pablo (author)
Chen, Guo-Bo (author)
Chen, Hsi-Chung (author)
Chillotti, Caterina (author)
Karolinska Institutet
Cichon, Sven (author)
Clark, Scott (author)
Colom, Francesc (author)
Cousins, David (author)
Cruceanu, Cristiana (author)
Czerski, Piotr (author)
Dantas, Clarissa (author)
Dayer, Alexandre (author)
Degenhardt, Franziska (author)
DePaulo, J Raymond (author)
Etain, Bruno (author)
Falkai, Peter (author)
Fellendorf, Frederike (author)
Ferensztajn-Rochowiak, Ewa (author)
Forstner, Andreas J (author)
Frisen, Louise (author)
Karolinska Institutet
Frye, Mark (author)
Fullerton, Janice (author)
Gard, Sebastien (author)
Garnham, Julie (author)
Goes, Fernando (author)
Grigoroiu-Serbanescu, Maria (author)
Grof, Paul (author)
Gruber, Oliver (author)
Hashimoto, Ryota (author)
Hauser, Joanna (author)
Heilbronner, Urs (author)
Herms, Stefan (author)
Hoffmann, Per (author)
Hofmann, Andrea (author)
Hou, Liping (author)
Jamain, Stéphane (author)
Jiménez, Esther (author)
Kahn, Jean-Pierre (author)
Kassem, Layla (author)
Kato, Tadafumi (author)
Kittel-Schneider, Sarah (author)
König, Barbara (author)
Kuo, Po-Hsiu (author)
Kusumi, Ichiro (author)
Dalkner, Nina (author)
Laje, Gonzalo (author)
Landén, Mikael, 1966 (author)
Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Lavebratt, Catharina (author)
Leboyer, Marion (author)
Leckband, Susan (author)
Jaramillo, Carlos López (author)
MacQueen, Glenda (author)
Maj, Mario (author)
Karolinska Institutet
Manchia, Mirko (author)
Marie-Claire, Cynthia (author)
Martinsson, Lina (author)
Karolinska Institutet
Mattheisen, Manuel (author)
McCarthy, Michael (author)
McElroy, Susan (author)
McMahon, Francis (author)
Mitchell, Philip (author)
Mitjans, Marina (author)
Mondimore, Francis (author)
Monteleone, Palmiero (author)
Nievergelt, Caroline (author)
Nöthen, Markus (author)
Novak, Tomas (author)
Osby, Urban (author)
Ozaki, Norio (author)
Papiol, Sergi (author)
Perlis, Roy (author)
Pfennig, Andrea (author)
Potash, James (author)
Reich-Erkelenz, Daniela (author)
Reif, Andreas (author)
Reininghaus, Eva (author)
Rietschel, Marcella (author)
Rouleau, Guy (author)
Rybakowski, Janusz K (author)
Schalling, Martin (author)
Schofield, Peter (author)
Schubert, Klaus Oliver (author)
Schulze, Thomas (author)
Schweizer, Barbara (author)
Seemüller, Florian (author)
Severino, Giovanni (author)
Shekhtman, Tatyana (author)
Shilling, Paul (author)
Shimoda, Kazutaka (author)
Simhandl, Christian (author)
Slaney, Claire (author)
Squassina, Alessio (author)
Stamm, Thomas (author)
Stopkova, Pavla (author)
Tighe, Sarah (author)
Tortorella, Alfonso (author)
Turecki, Gustavo (author)
Vieta, Eduard (author)
Volkert, Julia (author)
Witt, Stephanie (author)
Wray, Naomi (author)
Wright, Adam (author)
Young, Trevor (author)
Zandi, Peter (author)
Zompo, Maria Del (author)
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 (creator_code:org_t)
2023
English.
In: Research square.
  • Other publication (other academic/artistic)
Abstract Subject headings
Close  
  • Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Publication and Content Type

vet (subject category)
ovr (subject category)

To the university's database

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By the author/editor
Kelsoe, John
Ou, Anna
Rosenthal, Sara
Adli, Mazda
Akiyama, Kazufum ...
Akula, Nirmala
show more...
Alda, Martin
Amare, Azmeraw T
Ardau, Raffaella
Arias, Bárbara
Aubry, Jean-Mich ...
Backlund, Lena
Banzato, Claudio
Bauer, Michael
Baune, Bernhard
Bellivier, Frank
Benabarre, Anton ...
Bengesser, Susan ...
Abesh, Bhattacha ...
Biernacka, Joann ...
Bui, Elise
Cervantes, Pablo
Chen, Guo-Bo
Chen, Hsi-Chung
Chillotti, Cater ...
Cichon, Sven
Clark, Scott
Colom, Francesc
Cousins, David
Cruceanu, Cristi ...
Czerski, Piotr
Dantas, Clarissa
Dayer, Alexandre
Degenhardt, Fran ...
DePaulo, J Raymo ...
Etain, Bruno
Falkai, Peter
Fellendorf, Fred ...
Ferensztajn-Roch ...
Forstner, Andrea ...
Frisen, Louise
Frye, Mark
Fullerton, Janic ...
Gard, Sebastien
Garnham, Julie
Goes, Fernando
Grigoroiu-Serban ...
Grof, Paul
Gruber, Oliver
Hashimoto, Ryota
Hauser, Joanna
Heilbronner, Urs
Herms, Stefan
Hoffmann, Per
Hofmann, Andrea
Hou, Liping
Jamain, Stéphane
Jiménez, Esther
Kahn, Jean-Pierr ...
Kassem, Layla
Kato, Tadafumi
Kittel-Schneider ...
König, Barbara
Kuo, Po-Hsiu
Kusumi, Ichiro
Dalkner, Nina
Laje, Gonzalo
Landén, Mikael, ...
Lavebratt, Catha ...
Leboyer, Marion
Leckband, Susan
Jaramillo, Carlo ...
MacQueen, Glenda
Maj, Mario
Manchia, Mirko
Marie-Claire, Cy ...
Martinsson, Lina
Mattheisen, Manu ...
McCarthy, Michae ...
McElroy, Susan
McMahon, Francis
Mitchell, Philip
Mitjans, Marina
Mondimore, Franc ...
Monteleone, Palm ...
Nievergelt, Caro ...
Nöthen, Markus
Novak, Tomas
Osby, Urban
Ozaki, Norio
Papiol, Sergi
Perlis, Roy
Pfennig, Andrea
Potash, James
Reich-Erkelenz, ...
Reif, Andreas
Reininghaus, Eva
Rietschel, Marce ...
Rouleau, Guy
Rybakowski, Janu ...
Schalling, Marti ...
Schofield, Peter
Schubert, Klaus ...
Schulze, Thomas
Schweizer, Barba ...
Seemüller, Flori ...
Severino, Giovan ...
Shekhtman, Tatya ...
Shilling, Paul
Shimoda, Kazutak ...
Simhandl, Christ ...
Slaney, Claire
Squassina, Aless ...
Stamm, Thomas
Stopkova, Pavla
Tighe, Sarah
Tortorella, Alfo ...
Turecki, Gustavo
Vieta, Eduard
Volkert, Julia
Witt, Stephanie
Wray, Naomi
Wright, Adam
Young, Trevor
Zandi, Peter
Zompo, Maria Del
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Psychiatry
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
Articles in the publication
By the university
University of Gothenburg
Karolinska Institutet

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