Physical exercise capacity is associated with coronary and peripheral vascular function in healthy young adults.

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Hägg Samuelsson, Ulrika,1973Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute (författare)

Short-term exercise training has been shown to improve cardiovascular function, whereas long-term effects of a physically active lifestyle, on coronary artery function in particular, are still not well studied. We explored possible relationships between physical exercise capacity and coronary and peripheral vascular function in healthy young adults. Twenty-nine healthy young male and female volunteers participated in the study. They underwent 1) basic clinical and echocardiographic characterization, 2) coronary flow velocity reserve (CFVR) measurement of the left anterior descending coronary artery (LAD), 3) common carotid artery (CCA) intima-media thickness (IMT) measurement, 4) assessment of CCA stiffness index (SI), 5) forearm flow-mediated vasodilation (FMD), and 6) submaximal exercise test. The calculated weight-adjusted maximal oxygen uptake capacity (Vo(2 max)(c)) was positively correlated to LAD CFVR and inversely correlated to IMT and SI. Also, subjects with high compared with moderate exercise capacity had higher FMD. In addition, subjects with LAD CFVR in the upper median had greater ratios between endothelium-dependent and -independent vasodilation in the forearm and lower SI in CCA. High exercise capacity due to a physically active lifestyle is associated with high coronary and peripheral artery function, indicating an early protective role of physical exercise for cardiovascular health.

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
Adult
Carotid Artery
Common
physiology
Coronary Circulation
physiology
Echocardiography
Doppler
Endothelium
Vascular
physiology
Exercise
physiology
Female
Forearm
blood supply
Humans
Life Style
Male
Regional Blood Flow
physiology
Vasodilation
physiology

Wandt, Birger,1951Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xwanbi (författare)
Bergström, Göran,1964Gothenburg University,Göteborgs universitet,Institutionen för fysiologi och farmakologi, Avdelningen för fysiologi,Institute of Physiology and Pharmacology, Dept of Physiology(Swepub:gu)xbgort (författare)
Volkmann, Reinhard,1942Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xvolkr (författare)
Gan, Li-Ming,1969Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xganli (författare)
Göteborgs universitetHjärt-kärlinstitutionen (creator_code:org_t)

Ingår i:American journal of physiology. Heart and circulatory physiology: American Physiological Society289:4, s. H1627-340363-61351522-1539

Av författaren/redakt...: Hägg Samuelsson, ...; Wandt, Birger, 1 ...; Bergström, Göran ...; Volkmann, Reinha ...; Gan, Li-Ming, 19 ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Fysiologi

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