Increased CSF/serum albumin ratio: a recurrent finding in violent offenders.

• OBJECTIVE: To test the hypothesis that cerebrospinal fluid (CSF)/ serum albumin ratios are increased in violent offenders. SUBJECTS AND METHODS: In a previous study of violent offenders, we found significantly higher CSF/serum album ratios (as a sign of increased blood-brain barrier permeability) in violent offenders than in healthy controls. For the present replication study, we recruited a new group of 28 violent offenders, aged 45 years or younger, and 20 new control subjects. RESULTS: The albumin ratio was again significantly higher in the offender group (mean 6.2) than in the control group (mean 4.6) (P = 0.012). Substance abuse or current medication did not appear to explain this finding. CONCLUSION: Increased CSF/serum albumin ratios are an unspecific sign of neurological dysfunction in subgroups of violent offenders.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Adolescent

Adult

Albumins

cerebrospinal fluid

Anxiety Disorders

epidemiology

Blood-Brain Barrier

physiopathology

Brain

metabolism

physiopathology

Brain Chemistry

physiology

Causality

Cerebrospinal Fluid Proteins

metabolism

Female

Humans

Male

Middle Aged

Mood Disorders

epidemiology

Personality Disorders

blood

cerebrospinal fluid

Predictive Value of Tests

Psychotic Disorders

epidemiology

Reference Values

Serum Albumin

metabolism

Substance-Related Disorders

epidemiology

Violence

psychology

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)