Patch Testing with a New Composition of the Mercapto Mix - A Multicenter Study from the International Contact Dermatitis Research Group

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Isaksson, MarléneLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital (författare)

Background Mercaptobenzothiazole compounds are associated with allergic contact dermatitis caused by rubber products. Several screening substances have been used for patch testing. Objective To compare the frequency of positive test reactions to a mercapto mix containing a higher concentration of 2-mercaptobenzothiazole with reactions to the combination of 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0%. Methods There were 7103 dermatitis patients in 12 International Contact Dermatitis Research Group dermatology departments who were patch tested with 2-mercaptobenzothiazole 2.0% petrolatum (pet.), mercapto mix 2.0% pet., and mercapto mix 3.5% pet. Results Contact allergy to the 3 test preparations varied among the 12 centers: 2-mercaptobenzothiazole 2.0% pet. (0-2.4%), mercapto mix 2.0% pet. (0-4.9%), and mercapto mix 3.5% pet. (0-1.4%). 2-Mercaptobenzothiazole 2.0% and mercapto mix 2.0% detected a few more positive patients compared with mercapto mix 3.5%, but the difference was statistically insignificant (mercapto mix 2.0% pet., P = 1.0; 2-mercapto-benzothiazole 2.0% pet., P = 0.66). Conclusions Mercapto mix 3.5% pet. is not better than 2-mercaptobenzothiazole 2.0% and mercapto mix 2.0% by a difference that is significant. By using only 1 test preparation (mercapto mix 3.5%), an additional hapten could be tested. No cases of suspected/proven patch test sensitization were registered.

Andersen, Klaus E.Odense University Hospital (författare)
Cannavó, AliciaHospital de Clínicas "José de San Martín" (författare)
Elsner, PeterUniversitätsklinikum Jena (författare)
Goh, Chee LeokNational Skin Centre (författare)
Gonçalo, MargaridaUniversity Hospital of Coimbra (författare)
Goossens, AnUniversity Hospitals Leuven (författare)
Hadzavdic, Suzana LjubojevicUniversity Hospital of Infectious Diseases (författare)
Pratt, MelanieThe Ottawa Hospital (författare)
Puangpet, PailinInstitute of Dermatology Thailand (författare)
Sasseville, DenisMcGill University Health Centre, Montreal General Hospital (författare)
Verma, KaushalAll India Institute of Medical Sciences (författare)
Bruze, MagnusLund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)derm-mbr (författare)
Yrkes- och miljödermatologiForskargrupper vid Lunds universitet (creator_code:org_t)

Av författaren/redakt...: Isaksson, Marlén ...; Andersen, Klaus ...; Cannavó, Alicia; Elsner, Peter; Goh, Chee Leok; Gonçalo, Margari ...; visa fler...; Goossens, An; Hadzavdic, Suzan ...; Pratt, Melanie; Puangpet, Pailin; Sasseville, Deni ...; Verma, Kaushal; Bruze, Magnus; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Dermatologi och ...

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