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  • Cook, Michael J.University of Manchester (author)

Frailty and bone health in European men

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-11-16
  • Oxford University Press (OUP),2017
  • 7 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:113e9dc7-347b-4aea-ac02-754e246d6675
  • https://lup.lub.lu.se/record/113e9dc7-347b-4aea-ac02-754e246d6675URI
  • https://doi.org/10.1093/ageing/afw205DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: frailty is associated with an increased risk of fragility fractures. Less is known, however, about the association between frailty and bone health.Methods: men aged 40-79 years were recruited from population registers in eight European centres for participation in the European Male Aging Study. Subjects completed a comprehensive assessment which included quantitative ultrasound (QUS) scan of the heel (Hologic-SAHARA) and in two centres, dual-energy bone densitometry (dual-energy x-ray absorptiometry, DXA). Frailty was defined based on an adaptation of Fried's phenotype criteria and a frailty index (FI) was constructed. The association between frailty and the QUS and DXA parameters was determined using linear regression, with adjustments for age, body mass index and centre.Results: in total, 3,231 subjects contributed data to the analysis. Using the Fried categorisation of frailty, pre-frail and frail men had significantly lower speed of sound (SOS), broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) compared to robust men (P< 0.05). Similar results were seen using the FI after categorisation into 'high', 'medium' and 'low' levels of frailty. Using the Fried categorisation, frail men had lower femoral neck bone mineral density (BMD) compared to robust men (P < 0.05), but not lower lumbar spine BMD. Using the FI categorisation, a 'high' level of frailty (FI > 0.35) was associated with lower lumbar spine BMD (P < 0.05) when compared to those with low (FI < 0.2), but not lower femoral neck BMD. When analysed as a continuous variable, higher FI was linked with lower SOS, BUA and QUI (P < 0.05).Conclusions: optimisation of bone health as well as prevention of falls should be considered as strategies to reduce fractures in frail older people.

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  • Oldroyd, AlexanderUniversity of Manchester (author)
  • Pye, Stephen RUniversity of Manchester,Great Ormond Street Hospital (author)
  • Ward, Kate AMRC Human Nutrition Research (author)
  • Gielen, EvelienCatholic University of Leuven (author)
  • Ravindrarajah, RathiKing's College London (author)
  • Adams, Judith EUniversity of Manchester (author)
  • Lee, David MUniversity of Manchester (author)
  • Bartfai, GyorgyUniversity of Szeged (author)
  • Boonen, StevenCatholic University of Leuven (author)
  • Casanueva, FelipeCIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN) (author)
  • Forti, GianniUniversity of Florence (author)
  • Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi (author)
  • Han, Thang SRoyal Holloway University of London (author)
  • Huhtaniemi, Ilpo T.Imperial College London (author)
  • Kula, KrzysztofMedical University of Lodz (author)
  • Lean, Michael E.University of Glasgow (author)
  • Pendleton, NeilUniversity of Manchester (author)
  • Punab, MargusTartu University Hospital (author)
  • Vanderschueren, DirkCatholic University of Leuven (author)
  • Wu, Frederick CUniversity of Manchester (author)
  • O'Neill, Terence W.Great Ormond Street Hospital (author)
  • Petrone, Luisa (author)
  • Cilotti, Antonio (author)
  • Borghs, Herman (author)
  • Slowikowska-Hilczer, Jolanta (author)
  • Walczak-Jedrzejowska, Renata (author)
  • Huhtaniemi, Ilpo (author)
  • Wu, Frederick Cw (author)
  • Silman, Alan (author)
  • O'Neill, Terence (author)
  • Finn, Joseph D (author)
  • Steer, Philip (author)
  • Tajar, Abdelouahid (author)
  • Lee, David (author)
  • Pye, Stephen (author)
  • Ocampo, Marta (author)
  • Lage, Mary (author)
  • Földesi, Imre (author)
  • Fejes, Imre (author)
  • Korrovitz, Paul (author)
  • Jiang, Min (author)
  • University of ManchesterGreat Ormond Street Hospital (creator_code:org_t)
  • EMAS Study Group

Related titles

  • In:Age and Ageing: Oxford University Press (OUP)46:4, s. 635-6410002-07291468-2834

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