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Umbilical cord blood DNA methylation in children who later develop type 1 diabetes

Laajala, Essi (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland; Turku Doctoral Programme of Molecular Medicine, University of Turku, Turku, Finland; Department of Computer Science, Aalto University, Espoo, Finland
Ullah, Ubaid (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland
Grönroos, Toni (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland
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Rasool, Omid (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland
Aho, Viivi Halla (författare)
Department of Computer Science, Aalto University, Espoo, Finland
Konki, Mikko (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Kattelus, Roosa (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland
Mykkänen, Juha (författare)
Research Centre of Applied and Preventive Cardiovascular Medicine, Institute of Biomedicine, University of Turku, Turku, Finland
Nurmio, Mirja (författare)
Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Mäkilä, Mari Vahä (författare)
Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland
Kallionpää, Henna (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Lietzén, Niina (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Laiho, Asta (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Hyöty, Heikki (författare)
Department of Virology, Faculty of Medicine and Biosciences, University of Tampere, Tampere, Finland
Elo, Laura L. (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland
Ilonen, Jorma (författare)
Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
Knip, Mikael (författare)
Pediatric Research Center, Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Center for Child Health Research, Tampere University Hospital, Tampere, Finland
Lund, Riikka J. (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Veijola, Riitta (författare)
Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, Oulu, Finland
Lähdesmäki, Harri (författare)
Department of Computer Science, Aalto University, Espoo, Finland
Toppari, Jorma (författare)
Research Centre for Integrative Physiology and Pharmacology, Institute of Biomedicine, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland
Lahesmaa, Riitta (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, Turku, Finland
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 (creator_code:org_t)
John Wiley & Sons, 2021
2021
Engelska.
Ingår i: European Journal of Immunology. - : John Wiley & Sons. - 0014-2980 .- 1521-4141. ; 51:Suppl. 1, s. 291-291
Relaterad länk:
https://urn.kb.se/re...
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
Abstract Ämnesord
Stäng  
  • Distinct DNA methylation patterns have recently been observed to precede Type 1 Diabetes in whole blood collected from young children. Our aim was to determine if such methylation patterns are present already at the time of birth. Reduced representation bisulfite sequencing (RRBS) analysis was performed on a unique collection of umbilical cord blood samples collected within the Type 1 Diabetes Prediction and Prevention (DIPP) study. Children later diagnosed with Type 1 Diabetes and/or testing positive for multiple islet autoantibodies (N=43) were compared to control individuals (N=79), who remained autoantibody‐negative throughout the DIPP follow‐up until 15 years of age. Altogether 24 clinical and technical covariates related to the pregnancy and the mother were included in a binomial mixed effects model, which was fit separately for each high‐coverage CpG site, followed by spatial and multiple testing adjustment of P values. We discovered a strong inflation of P values, which was caused by a standard spatial adjustment method. Findings that were based on Benjamini‐Hochberg corrected spatially adjusted P values, could not be validated by Pyrosequencing. We therefore used permutation‐based significance analysis and showed that sex‐associated differentially methylated cytosines could be reproducibly detected with this approach. After empirical type 1 error control, no differences in cord blood methylation patterns were observed between cases and controls. Differences between children who progress to Type 1 Diabetes and those who remain healthy throughout childhood, are not yet present in the perinatal DNA methylome.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Immunology in the medical area (hsv//eng)

Nyckelord

Autoimmunity
diabetes
molecular immunology

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