Spatial transcriptomics of human placentas reveal distinct RNA patterns associated with morphology and preeclampsia

• Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associated structures, RNA levels differed between placentas from full term healthy pregnancies and those complicated by preeclampsia. The results from this study can provide a benchmark for future ST studies in placenta.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)

Nyckelord

Differential gene expression

Hemoglobin

Morphology

Oxidoreductase pathway

Placenta

Preeclampsia

Pregnancy complications

Spatial transcriptomics

Villi

Differential gene expression

Hemoglobin

Morphology

Oxidoreductase pathway

Placenta

Preeclampsia

Pregnancy complications

Spatial transcriptomics

Villi

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