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Sökning: WFRF:(Wareham Nick J.) > (2020) > Thysell Elin > Lifestyle factors a...

  • Freisling, HeinzInternational Agency for Research on Cancer, World Health Organization (författare)

Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases : a multinational cohort study

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-01-10
  • Springer Science and Business Media LLC,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:494de5fe-0a96-4e95-9cb3-0aa5d1ff1f93
  • https://lup.lub.lu.se/record/494de5fe-0a96-4e95-9cb3-0aa5d1ff1f93URI
  • https://doi.org/10.1186/s12916-019-1474-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168685URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • BACKGROUND: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. METHODS: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. RESULTS: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and women with healthy lifestyles. CONCLUSION: Pre-diagnostic healthy lifestyle behaviours were strongly inversely associated with the risk of cancer and cardiometabolic diseases, and with the prognosis of these diseases by reducing risk of multimorbidity.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Viallon, VivianInternational Agency for Research on Cancer, World Health Organization (författare)
  • Lennon, HannahInternational Agency for Research on Cancer, World Health Organization (författare)
  • Bagnardi, VincenzoUniversity of Milano-Bicocca (författare)
  • Ricci, CristianNorth-West University (författare)
  • Butterworth, Adam S.University of Cambridge (författare)
  • Sweeting, MichaelUniversity of Cambridge (författare)
  • Muller, DavidImperial College London (författare)
  • Romieu, IsabelleInternational Agency for Research on Cancer, World Health Organization (författare)
  • Bazelle, PaulineInternational Agency for Research on Cancer, World Health Organization (författare)
  • Kvaskoff, MarinaCentre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay (författare)
  • Arveux, PatrickCentre Georges-François Leclerc,Centre for Research in Epidemiology and Population Health (CESP),Breast and Gynaecologic Cancer Registry of Côte d'Or (författare)
  • Severi, GianlucaUniversity of Paris-Saclay,Human Genetics Foundation (HuGeF),Centre for Research in Epidemiology and Population Health (CESP) (författare)
  • Bamia, ChristinaHellenic Health Foundation, Athens,National and Kapodistrian University of Athens (författare)
  • Kühn, TilmanGerman Cancer Research Centre (författare)
  • Kaaks, RudolfGerman Cancer Research Centre (författare)
  • Bergmann, ManuelaGerman Institute of Human Nutrition (författare)
  • Boeing, HeinerGerman Institute of Human Nutrition (författare)
  • Tjønneland, AnneDanish Cancer Society (författare)
  • Olsen, AnjaDanish Cancer Society (författare)
  • Overvad, KimAarhus University (författare)
  • Dahm, Christina C.Aarhus University (författare)
  • Menéndez, VirginiaPublic Health Directorate (författare)
  • Agudo, AntonioBellvitge University Hospital-IDIBELL,Bellvitge Biomedical Research Institute,L'Hospitalet de Llobregat, Barcelona,University of Oxford (författare)
  • Sánchez, Maria JoseUniversity of Granada,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Amiano, PilarBiodonostia Health Research Institute,CIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Santiuste, CarmenMurcia Regional Health Council (författare)
  • Gurrea, Aurelio BarricarteCIBER Epidemiology and Public Health (CIBERESP) (författare)
  • Tong, Tammy Y.N.University of Oxford (författare)
  • Schmidt, Julie A.University of Oxford (författare)
  • Tzoulaki, IoannaUniversity of Ioannina,Imperial College London (författare)
  • Tsilidis, Konstantinos K.University of Ioannina,Imperial College London (författare)
  • Ward, HeatherImperial College London (författare)
  • Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO) (författare)
  • Agnoli, ClaudiaIstituto Nazionale dei Tumori (författare)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (författare)
  • Ricceri, FulvioCitta' della Salute e della Scienza Hospital-University of Turin (författare)
  • Panico, SalvatoreUniversity of Naples Federico II (författare)
  • Picavet, H. Susan J.National Institute for Public Health and the Environment (RIVM) (författare)
  • Bakker, MarijeUniversity Medical Center Utrecht (författare)
  • Monninkhof, EvelynUniversity Medical Center Utrecht (författare)
  • Nilsson, PeterUmeå universitet,Umeå University,Näringsforskning (författare)
  • Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital(Swepub:lu)smi-jma (författare)
  • Rolandsson, OlovUmeå universitet,Umeå University,Allmänmedicin(Swepub:umu)olro0005 (författare)
  • Thysell, ElinUmeå University (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization (författare)
  • Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization (författare)
  • Riboli, ElioImperial College London (författare)
  • Vineis, PaoloImperial College London (författare)
  • Danesh, JohnUniversity of Cambridge (författare)
  • Wareham, Nick JUniversity of Cambridge (författare)
  • Gunter, Marc J.International Agency for Research on Cancer, World Health Organization (författare)
  • Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization (författare)
  • International Agency for Research on Cancer, World Health OrganizationUniversity of Milano-Bicocca (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Medicine: Springer Science and Business Media LLC18:11741-7015

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