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Sökning: WFRF:(Gimsing Peter) > Melphalan and predn...

Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myeloma

Waage, Anders (författare)
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway,NTNU
Gimsing, Peter (författare)
Department of Hematology, Rigshospitalet and University of Copenhagen
Fayers, Peter (författare)
Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
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Abildgaard, Niels (författare)
Department of Hematology, Odense University Hospital, Odense, Denmark
Ahlberg, Lucia (författare)
Östergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Hematologiska kliniken US
Björkstrand, Bo (författare)
Hematology Centre, Karolinska University Hospital/Huddinge, Stockholm, Sweden
Carlson, Kristina (författare)
Uppsala universitet,Medicin,Hematologi,Department of Hematology, Uppsala University Hospital, Uppsala, Sweden
Forsberg, Karin (författare)
Umeå universitet,Onkologi,Norrland University Hospital
Dahl, Inger Marie (författare)
Department of Medicine, University Hospital Tromsø, Tromsø, Norway
Gulbrandsen, Nina (författare)
Department of Hematology, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway
Haukas, Einar (författare)
Department of Medicine, Stavanger University Hospital, Stavanger, Norway
Hjertner, Öyvind (författare)
Department of Hematology, St Olavs Hospital and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
Hjorth, Martin (författare)
Department of Hematology, Lidköping Hospital, Lidköping, Sweden
Karlsson, Torbjörn (författare)
Uppsala universitet,Medicin,Hematologi,Department of Internal Medicine, Capio Sankt Görans Hospital, Stockholm, Sweden
Knudsen, Lene Meldgaard (författare)
Department of Hematology, Herlev Hospital, Copenhagen, Denmark
Nielsen, Johan Lanng (författare)
Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
Linder, Olle (författare)
Department of Medicine, Örebro University Hospital, Örebro, Sweden
Mellqvist, Ulf-Henrik (författare)
Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Nesthus, Ingerid (författare)
Department of Medicine, Haukeland University Hospital, Bergen, Norway
Rolke, Jurgen (författare)
Department of Medicine, Kristiansand Hospital, Kristiansand, Norway
Strandberg, Maria (författare)
Department of Medicine, Sundsvalls Hospital, Sundsvall, Sweden
Sörbo, Jon Hjalmar (författare)
Department of Medicine, Levanger Hospital, Levanger, Norway
Wislöff, Finn (författare)
Department of Hematology, Ullevål University Hospital and Faculty of Medicine, University of Oslo, Oslo, Norway
Juliusson, Gunnar (författare)
Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund University Hospital, Lund, Sweden
Turesson, Ingemar (författare)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Department of Medicine, Malmö University Hospital, Malmö, Sweden
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 (creator_code:org_t)
American Society of Hematology, 2010
2010
Engelska.
Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 116:9, s. 1405-1412
Relaterad länk:
http://dx.doi.org/10...
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https://urn.kb.se/re...
https://doi.org/10.1...
https://lup.lub.lu.s...
https://urn.kb.se/re...
https://urn.kb.se/re...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • In this double-blind, placebo-controlled study, 363 patients with untreated multiple myeloma were randomized to receive either melphalan-prednisone and thalidomide (MPT) or melphalan-prednisone and placebo (MP). The dose of melphalan was 0.25 mg/kg and prednisone was 100 mg given daily for 4 days every 6 weeks until plateau phase. The dose of thalidomide/placebo was escalated to 400 mg daily until plateau phase and thereafter reduced to 200 mg daily until progression. A total of 357 patients were analyzed. Partial response was 34% and 33%, and very good partial response or better was 23% and 7% in the MPT and MP arms, respectively (P < .001). There was no significant difference in progression-free or overall survival, with median survival being 29 months in the MPT arm and 32 months in the MP arm. Most quality of life outcomes improved equally in both arms, apart from constipation, which was markedly increased in the MPT arm. Constipation, neuropathy, non-neuropathy neurologic toxicity, and skin reactions were significantly more frequent in the MPT arm. The number of thromboembolic events was equal in the 2 treatment arms. In conclusion, MPT had a significant antimyeloma effect, but this did not translate into improved survival. This trial was registered at www.clinicaltrials.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

MEDICINE
MEDICIN

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