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Hepcidin levels and gastric cancer risk in the EPIC-EurGast study

Jakszyn, Paula (författare)
Bellvitge Biomedical Research Institute
Fonseca-Nunes, Ana (författare)
Bellvitge Biomedical Research Institute
Lujan-Barroso, Leila (författare)
Bellvitge Biomedical Research Institute,University of Barcelona
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Aranda, Núria (författare)
Rovira i Virgili University (URV)
Tous, Mónica (författare)
Rovira i Virgili University (URV)
Arija, Victoria (författare)
Rovira i Virgili University (URV)
Cross, Amanda (författare)
Imperial College London
Bueno-De-Mesquita, Bas H. (författare)
National Institute for Public Health and the Environment (RIVM),University Medical Center Utrecht
Weiderpass, Elisabete (författare)
Karolinska Institutet,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø,Folkhälsan Research Center
Kaaks, Rudolf (författare)
German Cancer Research Centre
Sjöberg, Klas (författare)
Lund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups,Skåne University Hospital
Ohlsson, Bodil (författare)
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
Tumino, Rosario (författare)
Civic and M.P Arezzo Hospital
Palli, Domenico (författare)
Cancer Research and Prevention Institute (ISPO)
Ricceri, Fulvio (författare)
Regional Health Service
Fasanelli, Francesca (författare)
Regional Health Service
Krogh, Vittorio (författare)
Istituto Nazionale dei Tumori
Mattiello, Amalia (författare)
University of Naples Federico II
Jenab, Mazda (författare)
International Agency for Research on Cancer, World Health Organization
Gunter, Marc (författare)
International Agency for Research on Cancer, World Health Organization
Perez-Cornago, Aurora (författare)
University of Oxford
Khaw, Kay Tee (författare)
University of Cambridge
Tjønneland, Anne (författare)
Danish Cancer Society
Olsen, Anja (författare)
Danish Cancer Society
Overvad, Kim (författare)
Aarhus University
Trichopoulou, Antonia (författare)
National and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
Peppa, Eleni (författare)
Hellenic Health Foundation, Athens
Vasilopoulou, Effie (författare)
National and Kapodistrian University of Athens
Boeing, Heiner (författare)
German Institute of Human Nutrition
Sánchez-Cantalejo, Emilio (författare)
CIBER Epidemiology and Public Health (CIBERESP),University of Granada
Huerta, José María (författare)
CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council
Dorronsoro,, Miren (författare)
Basque Regional Health Department,Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
Barricarte, Aurelio (författare)
CIBER Epidemiology and Public Health (CIBERESP),Health Research Institute of Navarra (IDISNA),Murcia Regional Health Council,Basque Regional Health Department
Quirós, José Maria (författare)
Public Health Directorate,Basque Regional Health Department,Health Research Institute of Navarra (IDISNA),Murcia Regional Health Council,CIBER Epidemiology and Public Health (CIBERESP)
Peeters, Petra H (författare)
University Medical Center Utrecht,Imperial College London
Agudo, Antonio (författare)
Bellvitge Biomedical Research Institute
Kuhn, T (författare)
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 (creator_code:org_t)
2017-06-21
2017
Engelska 7 s.
Ingår i: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 141:5, s. 945-951
Relaterad länk:
http://dx.doi.org/10...
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https://onlinelibrar...
https://lup.lub.lu.s...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l = 0.96, 95% CI = 0.93–0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: −69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

cohort study
gastric cancer
hepcidin
iron homeostasis

Publikations- och innehållstyp

art (ämneskategori)
ref (ämneskategori)

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