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Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes

Hirvonen, M Karoliina (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
Lietzén, Niina (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Moulder, Robert (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland
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Bhosale, Santosh D (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
Koskenniemi, Jaakko (författare)
InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, Turku, Finland
Vähä-Mäkilä, Mari (författare)
Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
Nurmio, Mirja (författare)
Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; School of Medical Sciences
Ilonen, Jorma (författare)
Immunogenetics Laboratory, University of Turku, Turku, Finland
Toppari, Jorma (författare)
InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, Turku, Finland
Veijola, Riitta (författare)
Department of Pediatrics, Research Unit of Clinical Medicine, Medical Research Center, University of Oulu, Oulu, Finland; Department for Children and Adolescents, Medical Research Center, Oulu University Hospital, Oulu, Finland
Hyöty, Heikki (författare)
Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Fimlab Laboratories, Tampere, Finland
Lähdesmäki, Harri (författare)
Department of Computer Science, Aalto University School of Science, Aalto, Finland
Knip, Mikael (författare)
Pediatric Research Center, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland
Cheng, Lu (författare)
Department of Computer Science, Aalto University School of Science, Aalto, Finland
Lahesmaa, Riitta (författare)
Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, Finland; Institute of Biomedicine, University of Turku, Turku, Finland
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 (creator_code:org_t)
Nature Publishing Group, 2023
2023
Engelska.
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 13:1
Relaterad länk:
https://doi.org/10.1...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging process. To address this concern, we used mass spectrometry-based proteomics to analyse longitudinal pre-onset plasma sample series from children positive for multiple islet autoantibodies who had rapidly progressed to type 1 diabetes before 4 years of age (n = 10) and compared these with similar measurements from matched children who were either positive for a single autoantibody (n = 10) or autoantibody negative (n = 10). Following statistical analysis of the longitudinal data, targeted serum proteomics was used to verify 11 proteins putatively associated with the disease development in a similar yet independent and larger cohort of children who progressed to the disease within 5 years of age (n = 31) and matched autoantibody negative children (n = 31). These data reiterated extensive age-related trends for protein levels in young children. Further, these analyses demonstrated that the serum levels of two peptides unique for apolipoprotein C1 (APOC1) were decreased after the appearance of the first islet autoantibody and remained relatively less abundant in children who progressed to type 1 diabetes, in comparison to autoantibody negative children.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

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