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Sökning: WFRF:(Toppari Jorma) > Cord-Blood Lipidome...

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes

Lamichhane, Santosh (författare)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
Ahonen, Linda (författare)
Steno Diabetes Center Copenhagen, Gentofte, Denmark
Dyrlund, Thomas Sparholt (författare)
Steno Diabetes Center Copenhagen, Gentofte, Denmark
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Dickens, Alex M (författare)
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
Siljander, Heli (författare)
Children's Hospital, University of Helsinki, Helsinki University Hospital and Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland
Hyöty, Heikki (författare)
Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland; Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
Ilonen, Jorma (författare)
Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland; Clinical Microbiology, Turku University Hospital, Turku, Finland
Toppari, Jorma (författare)
Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland
Veijola, Riitta (författare)
Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland; Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik
Knip, Mikael (författare)
Children's Hospital, University of Helsinki, Helsinki University Hospital and Research Program Unit, Diabetes and Obesity, University of Helsinki, Helsinki, Finland; Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland; Folkhälsan Research Center, Helsinki, Finland
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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 (creator_code:org_t)
2019-01-21
2019
Engelska.
Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 9:1
Relaterad länk:
https://doi.org/10.3...
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https://www.mdpi.com...
https://urn.kb.se/re...
https://doi.org/10.3...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Previous studies suggest that children who progress to type 1 diabetes (T1D) later in life already have an altered serum lipid molecular profile at birth. Here, we compared cord blood lipidome across the three study groups: children who progressed to T1D (PT1D; n = 30), children who developed at least one islet autoantibody but did not progress to T1D during the follow-up (P1Ab; n = 33), and their age-matched controls (CTR; n = 38). We found that phospholipids, specifically sphingomyelins, were lower in T1D progressors when compared to P1Ab and the CTR. Cholesterol esters remained higher in PT1D when compared to other groups. A signature comprising five lipids was predictive of the risk of progression to T1D, with an area under the receiver operating characteristic curve (AUROC) of 0.83. Our findings provide further evidence that the lipidomic profiles of newborn infants who progress to T1D later in life are different from lipidomic profiles in P1Ab and CTR.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Autoimmunity
cord blood
lipidomics
metabolomics
type 1 diabetes

Publikations- och innehållstyp

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