Total desmosines in plasma and urine correlate with lung function.

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To evaluate the relationship between the matrix degradation biomarkers, desmosine and isodesmosine (desmosines), and lung function.Plasma and creatinine-corrected urinary total desmosines (P- and U-desmosines), lung function and carbon monoxide diffusion capacity (DL,CO) were measured in a cohort of subjects from the Swedish Twin Registry.Concentrations of U- and P-desmosines were measured in 349 and 318 subjects, respectively; approximately one-third of subjects had chronic obstructive pulmonary disease (COPD). Age, female gender, body mass index (BMI) and smoking were significantly associated with U-desmosines in a multiple linear regression analysis. In the overall population, after adjustments for age, gender, height, BMI and smoking, concentrations of U-desmosines were significantly correlated with all lung function measures, and P-desmosines with forced expiratory volume in 1 s and DL,CO (P<0.05). With the exception of residual volume versus P-desmosines, relationships between concentrations of desmosines and lung function measures were markedly stronger in subjects with COPD compared with those without COPD.These cross-sectional data showing associations between desmosines and several lung function variables suggest that desmosines, particularly U-desmosines, could be a useful biomarker of COPD status.

Engström, G (författare)
Gerhardsson de Verdier, M (författare)
Nihlén, UlfLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)lung-uni (författare)
Anderson, MKarolinska Institutet (författare)
Forsman-Semb, K (författare)
Svartengren, MKarolinska Institutet (författare)
Lungmedicin, allergologi och palliativ medicinSektion II (creator_code:org_t)

Ingår i:European Respiratory Journal: European Respiratory Society (ERS)1399-30030903-1936

Av författaren/redakt...: Lindberg, C A; Engström, G; Gerhardsson de V ...; Nihlén, Ulf; Anderson, M; Forsman-Semb, K; visa fler...; Svartengren, M; visa färre...

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