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Sökning: onr:"swepub:oai:lup.lub.lu.se:d9c3dc21-75af-4a6c-b7c7-53bc492d03dc" > The Parkinson's Dis...

  • Grenn, Francis P.National Institutes of Health, United States (författare)

The Parkinson's Disease Genome-Wide Association Study Locus Browser

  • Artikel/kapitelEngelska2020

Förlag, utgivningsår, omfång ...

  • 2020-08-31
  • Wiley,2020

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:d9c3dc21-75af-4a6c-b7c7-53bc492d03dc
  • https://lup.lub.lu.se/record/d9c3dc21-75af-4a6c-b7c7-53bc492d03dcURI
  • https://doi.org/10.1002/mds.28197DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Parkinson's disease (PD) is a neurodegenerative disease with an often complex component identifiable by genome-wide association studies. The most recent large-scale PD genome-wide association studies have identified more than 90 independent risk variants for PD risk and progression across more than 80 genomic regions. One major challenge in current genomics is the identification of the causal gene(s) and variant(s) at each genome-wide association study locus. The objective of the current study was to create a tool that would display data for relevant PD risk loci and provide guidance with the prioritization of causal genes and potential mechanisms at each locus. Methods: We included all significant genome-wide signals from multiple recent PD genome-wide association studies including themost recent PD risk genome-wide association study, age-at-onset genome-wide association study, progression genome-wide association study, and Asian population PD risk genome-wide association study. We gathered data for all genes 1 Mb up and downstream of each variant to allow users to assess which gene(s) are most associated with the variant of interest based on a set of self-ranked criteria. Multiple databases were queried for each gene to collect additional causal data. Results: We created a PD genome-wide association study browser tool (https://pdgenetics.shinyapps.io/GWASBrowser/) to assist the PD research community with the prioritization of genes for follow-up functional studies to identify potential therapeutic targets. Conclusions: Our PD genome-wide association study browser tool provides users with a useful method of identifying potential causal genes at all known PD risk loci from large-scale PD genome-wide association studies. We plan to update this tool with new relevant data as sample sizes increase and new PD risk loci are discovered.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kim, Jonggeol J.National Institutes of Health, United States (författare)
  • Makarious, Mary B.National Institutes of Health, United States (författare)
  • Iwaki, HirotakaData Tecnica International,National Institutes of Health, United States (författare)
  • Illarionova, AnastasiaGerman Center for Neurodegenerative Diseases (DZNE), Bonn (författare)
  • Brolin, KajsaLund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups(Swepub:lu)ka1517br (författare)
  • Kluss, Jillian H.National Institutes of Health, United States (författare)
  • Schumacher-Schuh, Artur F.Hospital de Clinicas de Porto Alegre (författare)
  • Leonard, HamptonData Tecnica International,National Institutes of Health, United States (författare)
  • Faghri, FarazData Tecnica International,National Institutes of Health, United States (författare)
  • Billingsley, KimberleyNational Institutes of Health, United States (författare)
  • Krohn, LynneMcGill University (författare)
  • Hall, AshleyUniversity of Liverpool (författare)
  • Diez-Fairen, MonicaMutua De Terrassa Hospital (författare)
  • Periñán, Maria TeresaUniversity Hospital Virgen del Rocío (författare)
  • Sandor, CynthiaCardiff University (författare)
  • Webber, CalebCardiff University (författare)
  • Fiske, Brian K.The Michael J. Fox Foundation for Parkinson’s Research (författare)
  • Gibbs, J. RaphaelNational Institutes of Health, United States (författare)
  • Nalls, Mike A.National Institutes of Health, United States,Data Tecnica International (författare)
  • Singleton, Andrew B.National Institutes of Health, United States (författare)
  • Bandres-Ciga, SaraNational Institutes of Health, United States (författare)
  • Reed, XylenaNational Institutes of Health, United States (författare)
  • Blauwendraat, CornelisNational Institutes of Health, United States (författare)
  • National Institutes of Health, United StatesData Tecnica International (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Movement Disorders: Wiley0885-31851531-8257

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