Tyck till om SwePub Sök
här!
Sökning: onr:"swepub:oai:lup.lub.lu.se:de89b13c-8a1b-438c-98a5-229f3b61333f" >
Randomized Trial of...
Randomized Trial of BCG Vaccination at Birth to Low-Birth-Weight Children: Beneficial Nonspecific Effects in the Neonatal Period?
- Artikel/kapitelEngelska2011
Förlag, utgivningsår, omfång ...
-
2011-07-15
-
Oxford University Press (OUP),2011
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:de89b13c-8a1b-438c-98a5-229f3b61333f
-
https://lup.lub.lu.se/record/2094062URI
-
https://doi.org/10.1093/infdis/jir240DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Background. Observational studies have suggested that BCG may have nonspecific beneficial effects on survival. Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG. Methods. In the period 2004-2008 we recruited 2320 LBW children in Bissau. The children were visited at home at 2, 6, and 12 months of age. With a pretrial infant mortality of 250 per 1000, we hypothesized a 25% reduction in infant mortality for LBW children. Results. Infant mortality was only 101 per 1000 during the trial. In the primary analysis, infant mortality was reduced insignificantly by 17% (mortality rate ratio [MRR] = .83 [.63-1.08]). In secondary analyses, early BCG vaccine was safe with an MRR of .49 (.21-1.15) after 3 days and .55 (.34-.89) after 4 weeks. The reduction in neonatal mortality was mainly due to fewer cases of neonatal sepsis, respiratory infection, and fever. The impact of early BCG on infant mortality was marked for children weighing <1.5 kg (MRR = .43 [.21-.85]) who had lower coverage for diphtheria-tetanus-pertussis vaccinations. Conclusions. Though early BCG did not reduce infant mortality significantly, it may have a beneficial effect in the neonatal period. This could be important for public health because BCG is often delayed in low-income countries.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Roth, AdamLund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups(Swepub:lu)med-amr
(författare)
-
Ravn, Henrik
(författare)
-
Napirna, Bitiguida Mutna
(författare)
-
Rodrigues, Amabelia
(författare)
-
Lisse, Ida Maria
(författare)
-
Stensballe, Lone
(författare)
-
Diness, Birgitte Rode
(författare)
-
Lausch, Karen Rokkedal
(författare)
-
Lund, Najaaraq
(författare)
-
Biering-Sorensen, Sofie
(författare)
-
Whittle, Hilton
(författare)
-
Benn, Christine Stabell
(författare)
-
Klinisk mikrobiologi, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Infectious Diseases: Oxford University Press (OUP)204:2, s. 245-2521537-66130022-1899
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Aaby, Peter
-
Roth, Adam
-
Ravn, Henrik
-
Napirna, Bitigui ...
-
Rodrigues, Amabe ...
-
Lisse, Ida Maria
-
visa fler...
-
Stensballe, Lone
-
Diness, Birgitte ...
-
Lausch, Karen Ro ...
-
Lund, Najaaraq
-
Biering-Sorensen ...
-
Whittle, Hilton
-
Benn, Christine ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Infektionsmedici ...
- Artiklar i publikationen
-
Journal of Infec ...
- Av lärosätet
-
Lunds universitet