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Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile

Heald, Adrian H. (författare)
The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester. Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford
Martin, Susan (författare)
Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter
Fachim, Helene (författare)
The Faculty of Biology, Medicine and Health and Manchester. Academic Health Sciences Centre, University of Manchester Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford
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Green, Harry D. (författare)
Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter
Young, Katherine G. (författare)
Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter
Malipatil, Nagaraj (författare)
The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester. Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford
Siddals, Kirk (författare)
The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester. Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford
Cortes, Gabriela (författare)
General Directorate for Quality and Health Education, Mexico City, Mexico
Tyrrell, Jessica (författare)
Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter
Wood, Andrew R (författare)
Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter
Beaumont, Robin N. (författare)
Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter
Frayling, Timothy M. (författare)
Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter
Donn, Rachelle (författare)
The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester
Prakash Narayanan, Ram (författare)
Institute of Ageing and Chronic Disease, University of Liverpool
Ollier, William (författare)
The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester. Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK
Gibson, Martin (författare)
The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester. Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford
Yaghootkar, Hanieh (författare)
Luleå tekniska universitet,Institutionen för hälsovetenskap,Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter. Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK
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The Faculty of Biology, Medicine and Health and Manchester Academic Health Sciences Centre, University of Manchester Department of Diabetes and Endocrinology, Salford Royal Hospital, Salford Genetics of Complex Traits, University of Exeter, Medical School, University of Exeter RILD Level 3, Royal Devon & Exeter Hospital, Barrack Road, Exeter (creator_code:org_t)
2021-02-11
2021
Engelska.
Ingår i: Diabetic Medicine. - : John Wiley & Sons. - 0742-3071 .- 1464-5491. ; 38:9
Relaterad länk:
https://doi.org/10.1...
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https://onlinelibrar...
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • AimsChange in weight, HbA1c, lipids, blood pressure and cardiometabolic events over time is variable in individuals with type 2 diabetes. We hypothesized that people with a genetic predisposition to a more favourable adiposity distribution could have a less severe clinical course/progression.MethodsWe involved people with type 2 diabetes from two UK‐based cohorts: 11,914 individuals with GP follow‐up data from the UK Biobank and 723 from Salford. We generated a ‘favourable adiposity’ genetic score and conducted cross‐sectional and longitudinal studies to test its association with weight, BMI, lipids, blood pressure, medication use and risk of myocardial infarction and stroke using 15 follow‐up time points with 1‐year intervals.ResultsThe ‘favourable adiposity’ genetic score was cross‐sectionally associated with higher weight (effect size per 1 standard deviation higher genetic score: 0.91kg [0.59,1.23]) and BMI (0.30kg/m2 [0.19,0.40]), but higher high‐density lipoprotein (0.02mmol/L [0.01,0.02]) and lower triglycerides (‐0.04mmol/L [‐0.07,‐0.02]) in the UK Biobank at baseline, and this pattern of association was consistent across follow‐up.There was a trend for participants with higher ‘favourable adiposity’ genetic score to have lower risk of myocardial infarction and/or stroke (odds ratio 0.79 [0.62,1.00]) compared to those with lower score. A one standard deviation higher score was associated with lower odds of using lipid‐lowering (0.91 [0.86,0.97]) and anti‐hypertensive medication (0.95 [0.91,0.99]).ConclusionsIn individuals with type 2 diabetes, having more ‘favourable adiposity’ alleles is associated with a marginally better lipid profile long‐term and having lower odds of requiring lipid‐lowering or anti‐hypertensive medication in spite of relatively higher adiposity.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

BMI
Ectopic fat
Favourable adiposity genetic score
HbA1c
Metabolic profile
myocardial infarction
stroke
Type 2 Diabetes

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