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  • Chung, Sun Ju (author)

Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease

  • Article/chapterEnglish2014

Publisher, publication year, extent ...

  • 2014-02-27
  • Wiley,2014

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:e956cbb6-27b2-4b6b-b665-4b9a84b62883
  • https://lup.lub.lu.se/record/4662569URI
  • https://doi.org/10.1002/mds.25841DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:129547395URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Biernacka, Joanna M. (author)
  • Armasu, Sebastian M. (author)
  • Anderson, Kari (author)
  • Frigerio, Roberta (author)
  • Aasly, Jan O. (author)
  • Annesi, Grazia (author)
  • Bentivoglio, Anna Rita (author)
  • Brighina, Laura (author)
  • Chartier-Harlin, Marie-Christine (author)
  • Goldwurm, Stefano (author)
  • Hadjigeorgiou, Georgios (author)
  • Jasinska-Myga, Barbara (author)
  • Jeon, Beom Seok (author)
  • Kim, Yun Joong (author)
  • Krueger, Rejko (author)
  • Lesage, Suzanne (author)
  • Markopoulou, Katerina (author)
  • Mellick, George (author)
  • Morrison, Karen E. (author)
  • Puschmann, AndreasLund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-aps (author)
  • Tan, Eng-King (author)
  • Crosiers, David (author)
  • Theuns, Jessie (author)
  • Van Broeckhoven, Christine (author)
  • Wirdefeldt, KarinKarolinska Institutet (author)
  • Wszolek, Zbigniew K. (author)
  • Elbaz, Alexis (author)
  • Maraganore, Demetrius M. (author)
  • Neurologi, LundSektion IV (creator_code:org_t)

Related titles

  • In:Movement Disorders: Wiley29:8, s. 1053-10570885-3185
  • In:Movement disorders : official journal of the Movement Disorder Society: Wiley29:8, s. 1053-10571531-8257

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