Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

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MARC

Gusev, A (author)

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation

Article/chapterEnglish2016

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2016-04-07
Springer Science and Business Media LLC,2016

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:133315652
http://kipublications.ki.se/Default.aspx?queryparsed=id:133315652URI
https://doi.org/10.1038/ncomms10979DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-122103URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.

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Shi, H (author)
Kichaev, G (author)
Pomerantz, M (author)
Li, F (author)
Long, HW (author)
Ingles, SA (author)
Kittles, RA (author)
Strom, SS (author)
Rybicki, BA (author)
Nemesure, B (author)
Isaacs, WB (author)
Zheng, W (author)
Pettaway, CA (author)
Yeboah, ED (author)
Tettey, Y (author)
Biritwum, RB (author)
Adjei, AA (author)
Tay, E (author)
Truelove, A (author)
Niwa, S (author)
Chokkalingam, AP (author)
John, EM (author)
Murphy, ABKarolinska Institutet (author)
Signorello, LB (author)
Carpten, J (author)
Leske, MC (author)
Wu, SY (author)
Johansson, MattiasUmeå universitet,Enheten för biobanksforskning,Urologi och andrologi(Swepub:umu)masmas97 (author)
Neslund-Dudas, C (author)
Hsing, AW (author)
Chu, L (author)
Goodman, PJ (author)
Klein, EA (author)
Witte, JS (author)
Casey, G (author)
Kaggwa, S (author)
Cook, MB (author)
Stram, DO (author)
Blot, WJ (author)
Eeles, RA (author)
Easton, D (author)
Kote-Jarai, Z (author)
Al Olama, AA (author)
Benlloch, S (author)
Muir, K (author)
Giles, GG (author)
Southey, MC (author)
Fitzgerald, LM (author)
Gronberg, HKarolinska Institutet (author)
Wiklund, FKarolinska Institutet (author)
Aly, MKarolinska Institutet (author)
Henderson, BE (author)
Schleutker, J (author)
Wahlfors, T (author)
Tammela, TLJ (author)
Nordestgaard, BG (author)
Key, TJ (author)
Travis, RC (author)
Neal, DE (author)
Donovan, JL (author)
Hamdy, FC (author)
Pharoah, P (author)
Pashayan, N (author)
Khaw, KT (author)
Stanford, JL (author)
Thibodeau, SN (author)
McDonnell, SK (author)
Schaid, DJ (author)
Maier, C (author)
Vogel, W (author)
Luedeke, M (author)
Herkommer, K (author)
Kibel, AS (author)
Cybulski, C (author)
Wokolorczyk, D (author)
Kluzniak, W (author)
Cannon-Albright, L (author)
Teerlink, C (author)
Brenner, H (author)
Dieffenbach, AK (author)
Arndt, V (author)
Park, JY (author)
Sellers, TA (author)
Lin, HY (author)
Slavov, C (author)
Kaneva, R (author)
Mitev, V (author)
Batra, J (author)
Spurdle, A (author)
Clements, JAKarolinska Institutet (author)
Teixeira, MR (author)
Pandha, H (author)
Michael, A (author)
Paulo, P (author)
Maia, S (author)
Kierzek, A (author)
Conti, DV (author)
Albanes, D (author)
Berg, C (author)
Berndt, SI (author)
Campa, D (author)
Crawford, ED (author)
Diver, WR (author)
Gapstur, SM (author)
Gaziano, JM (author)
Giovannucci, E (author)
Hoover, R (author)
Hunter, DJ (author)
Johansson, M (author)
Kraft, P (author)
Le Marchand, L (author)
Lindstrom, S (author)
Navarro, C (author)
Overvad, K (author)
Riboli, E (author)
Siddiq, A (author)
Stevens, VL (author)
Trichopoulos, D (author)
Vineis, P (author)
Yeager, M (author)
Trynka, G (author)
Raychaudhuri, S (author)
Schumacher, FR (author)
Price, AL (author)
Freedman, ML (author)
Haiman, CA (author)
Pasaniuc, B (author)
Cook, M (author)
Guy, M (author)
Govindasami, K (author)
Leongamornlert, D (author)
Sawyer, EJ (author)
Wilkinson, R (author)
Saunders, EJ (author)
Tymrakiewicz, M (author)
Dadaev, T (author)
Morgan, A (author)
Fisher, C (author)
Hazel, S (author)
Livni, N (author)
Lophatananon, A (author)
Pedersen, J (author)
Hopper, JL (author)
Adolfson, JKarolinska Institutet (author)
Stattin, P (author)
Johansson, JE (author)
Cavalli-Bjoerkman, C (author)
Karlsson, A (author)
Broms, M (author)
Auvinen, A (author)
Kujala, P (author)
Maeaettaenen, L (author)
Murtola, T (author)
Taari, K (author)
Weischer, M (author)
Nielsen, SF (author)
Klarskov, P (author)
Roder, A (author)
Iversen, P (author)
Wallinder, H (author)
Gustafsson, S (author)
Cox, A (author)
Brown, P (author)
George, A (author)
Marsden, G (author)
Lane, A (author)
Davis, M (author)
Zheng, W (author)
Signorello, LB (author)
Blot, WJ (author)
Tillmans, L (author)
Riska, S (author)
Wang, L (author)
Rinckleb, A (author)
Lubiski, J (author)
Stegmaier, C (author)
Pow-Sang, J (author)
Park, H (author)
Radlein, S (author)
Rincon, M (author)
Haley, J (author)
Zachariah, B (author)
Kachakova, D (author)
Popov, E (author)
Mitkova, A (author)
Vlahova, A (author)
Dikov, T (author)
Christova, S (author)
Heathcote, P (author)
Wood, G (author)
Malone, G (author)
Saunders, P (author)
Eckert, A (author)
Yeadon, T (author)
Kerr, K (author)
Collins, A (author)
Turner, M (author)
Srinivasan, S (author)
Kedda, MA (author)
Alexander, K (author)
Omara, T (author)
Wu, HH (author)
Henrique, R (author)
Pinto, P (author)
Santos, J (author)
Barros-Silva, J (author)
Karolinska InstitutetEnheten för biobanksforskning (creator_code:org_t)

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In:Nature communications: Springer Science and Business Media LLC7, s. 10979-2041-1723

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By the author/editor: Gusev, A; Shi, H; Kichaev, G; Pomerantz, M; Li, F; Long, HW; show more...; Ingles, SA; Kittles, RA; Strom, SS; Rybicki, BA; Nemesure, B; Isaacs, WB; Zheng, W; Pettaway, CA; Yeboah, ED; Tettey, Y; Biritwum, RB; Adjei, AA; Tay, E; Truelove, A; Niwa, S; Chokkalingam, AP; John, EM; Murphy, AB; Signorello, LB; Carpten, J; Leske, MC; Wu, SY; Johansson, Matti ...; Neslund-Dudas, C; Hsing, AW; Chu, L; Goodman, PJ; Klein, EA; Witte, JS; Casey, G; Kaggwa, S; Cook, MB; Stram, DO; Blot, WJ; Eeles, RA; Easton, D; Kote-Jarai, Z; Al Olama, AA; Benlloch, S; Muir, K; Giles, GG; Southey, MC; Fitzgerald, LM; Gronberg, H; Wiklund, F; Aly, M; Henderson, BE; Schleutker, J; Wahlfors, T; Tammela, TLJ; Nordestgaard, BG; Key, TJ; Travis, RC; Neal, DE; Donovan, JL; Hamdy, FC; Pharoah, P; Pashayan, N; Khaw, KT; Stanford, JL; Thibodeau, SN; McDonnell, SK; Schaid, DJ; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, ...; Teerlink, C; Brenner, H; Dieffenbach, AK; Arndt, V; Park, JY; Sellers, TA; Lin, HY; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Spurdle, A; Clements, JA; Teixeira, MR; Pandha, H; Michael, A; Paulo, P; Maia, S; Kierzek, A; Conti, DV; Albanes, D; Berg, C; Berndt, SI; Campa, D; Crawford, ED; Diver, WR; Gapstur, SM; Gaziano, JM; Giovannucci, E; Hoover, R; Hunter, DJ; Johansson, M; Kraft, P; Le Marchand, L; Lindstrom, S; Navarro, C; Overvad, K; Riboli, E; Siddiq, A; Stevens, VL; Trichopoulos, D; Vineis, P; Yeager, M; Trynka, G; Raychaudhuri, S; Schumacher, FR; Price, AL; Freedman, ML; Haiman, CA; Pasaniuc, B; Cook, M; Guy, M; Govindasami, K; Leongamornlert, ...; Sawyer, EJ; Wilkinson, R; Saunders, EJ; Tymrakiewicz, M; Dadaev, T; Morgan, A; Fisher, C; Hazel, S; Livni, N; Lophatananon, A; Pedersen, J; Hopper, JL; Adolfson, J; Stattin, P; Johansson, JE; Cavalli-Bjoerkma ...; Karlsson, A; Broms, M; Auvinen, A; Kujala, P; Maeaettaenen, L; Murtola, T; Taari, K; Weischer, M; Nielsen, SF; Klarskov, P; Roder, A; Iversen, P; Wallinder, H; Gustafsson, S; Cox, A; Brown, P; George, A; Marsden, G; Lane, A; Davis, M; Tillmans, L; Riska, S; Wang, L; Rinckleb, A; Lubiski, J; Stegmaier, C; Pow-Sang, J; Park, H; Radlein, S; Rincon, M; Haley, J; Zachariah, B; Kachakova, D; Popov, E; Mitkova, A; Vlahova, A; Dikov, T; Christova, S; Heathcote, P; Wood, G; Malone, G; Saunders, P; Eckert, A; Yeadon, T; Kerr, K; Collins, A; Turner, M; Srinivasan, S; Kedda, MA; Alexander, K; Omara, T; Wu, HH; Henrique, R; Pinto, P; Santos, J; Barros-Silva, J; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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