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Organo-ptii complexes for potent photodynamic inactivation of multi-drug resistant bacteria and the influence of configuration

Chong, Hui (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
Liu, Xuanwei (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
Fang, Siyu (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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Yang, Xiaofei (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
Zhang, Yuefei (författare)
Department of Emergency, Affiliated Hospital of Yangzhou University, Jiangsu, Yangzhou, China
Wang, Tianyi (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
Liu, Lin (författare)
School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
Kan, Yinshi (författare)
School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
Zhao, Yueqi (författare)
School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
Fan, Hongying (författare)
Testing Center of Yangzhou University, No. 48 Wenhui East Rd., Yangzhou, China
Zhang, Jingqi (författare)
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China
Wang, Xiaoyu (författare)
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China
Yao, Hang (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
Yang, Yi (författare)
Center Laboratory, Affiliated Hospital of Yangzhou University, Yangzhou, China
Gao, Yijian (författare)
College of Pharmaceutical Sciences, Soochow University, Suzhou, China
Zhao, Qi (författare)
College of Pharmaceutical Sciences, Soochow University, Suzhou, China
Li, Shengliang (författare)
College of Pharmaceutical Sciences, Soochow University, Suzhou, China
Plymoth, Martin (författare)
Umeå universitet,Institutionen för klinisk mikrobiologi,Westmead hospital, NSW, Sydney, Australia
Xi, Juqun (författare)
Department of Pharmacology, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, Yangzhou, China
Zhang, Yu (författare)
School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
Wang, Chengyin (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
Pang, Huan (författare)
Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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Department of Chemical and Chemical Engineering, Yangzhou University, No 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China Department of Emergency, Affiliated Hospital of Yangzhou University, Jiangsu, Yangzhou, China (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Advanced Science. - : John Wiley & Sons. - 2198-3844.
Relaterad länk:
https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • PtII based organometallic photosensitizers (PSs) have emerged as novel potent photodynamic inactivation (PDI) reagents through their enhanced intersystem crossing (ISC) processes. Currently, few PtII PSs have been investigated as antibacterial materials, with relatively poor performances reported and with structure-activity relationships not well described. Herein, a pair of configurational isomers are reported of Bis-BODIPY (4,4-difluoro-boradizaindacene) embedded PtII PSs. The cis-isomer (cis-BBP) displayed enhanced 1O2 generation and better bacterial membrane anchoring capability as compared to the trans-isomer (trans-BBP). The effective PDI concentrations (efficiency > 99.9%) for cis-BBP in Acinetobacter baumannii (multi-drug resistant (MDR)) and Staphylococcus aureus are 400 nM (12 J cm−2) and 100 nM (18 J cm−2), respectively; corresponding concentrations and light doses for trans-BBP in the two bacteria are 2.50 µM (30 J cm−2) and 1.50 µM (18 J cm−2), respectively. The 50% and 90% minimum inhibitory concentration (MIC50 and MIC90) ratio of trans-BBP to cis-BBP is 22.22 and 24.02 in A. baumannii (MDR); 21.29 and 22.36 in methicillin resistant S. aureus (MRSA), respectively. Furthermore, cis-BBP displays superior in vivo antibacterial performance, with acceptable dark and photoinduced cytotoxicity. These results demonstrate cis-BBP is a robust light-assisted antibacterial reagent at sub-micromolecular concentrations. More importantly, configuration of PtII PSs should be an important issue to be considered in further PDI reagents design.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

Nyckelord

antibacterial agents
drug resistance
membrane anchoring
photosensitizers
PtII
reactive oxygen species
structure-activity relationship

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