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Genome-wide associa...
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-04-16
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Springer Science and Business Media LLC,2018
Numbers
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LIBRIS-ID:oai:prod.swepub.kib.ki.se:138066679
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138066679URI
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https://doi.org/10.1038/s41467-018-03819-3DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P < 5 × 10−8) across the three phenotypes. The direction of effect of these loci is consistently replicated in an independent sample, with 14 loci likely representing novel findings. Gene sets are enriched in excitatory neurotransmission, mechanosensory behaviour, post synapse, neuron spine and dendrite functions. Our findings suggest that broad depression is the most tractable UK Biobank phenotype for discovering genes and gene sets that further our understanding of the biological pathways underlying depression.
Added entries (persons, corporate bodies, meetings, titles ...)
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Adams, MJ
(author)
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Shirali, M
(author)
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Clarke, TK
(author)
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Marioni, RE
(author)
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Davies, G
(author)
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Coleman, JRI
(author)
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Alloza, C
(author)
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Shen, XY
(author)
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Barbu, MC
(author)
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Wigmore, EM
(author)
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Gibson, J
(author)
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Hagenaars, SP
(author)
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Lewis, CM
(author)
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Ward, J
(author)
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Smith, DJ
(author)
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Sullivan, PFKarolinska Institutet
(author)
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Haley, CS
(author)
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Breen, G
(author)
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Deary, IJ
(author)
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McIntosh, AM
(author)
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Karolinska Institutet
(creator_code:org_t)
Related titles
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In:Nature communications: Springer Science and Business Media LLC9:1, s. 1470-2041-1723
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- By the author/editor
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Howard, DM
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Adams, MJ
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Shirali, M
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Clarke, TK
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Marioni, RE
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Davies, G
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show more...
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Coleman, JRI
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Alloza, C
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Shen, XY
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Barbu, MC
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Wigmore, EM
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Gibson, J
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Hagenaars, SP
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Lewis, CM
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Ward, J
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Smith, DJ
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Sullivan, PF
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Haley, CS
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Breen, G
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Deary, IJ
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McIntosh, AM
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show less...
- Articles in the publication
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Nature communica ...
- By the university
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Karolinska Institutet