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Alzheimer's disease...
Alzheimer's disease cerebrospinal fluid biomarkers predict cognitive decline in lewy body dementia
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- Abdelnour, C. (author)
- Barcelona Alzheimer Treatment & Research Center
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- van Steenoven, I. (author)
- Amsterdam UMC - Vrije Universiteit Amsterdam
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- Londos, Elisabet (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Blanc, F. (author)
- University Hospital Of Strasbourg,University of Strasbourg
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- Auestad, B. (author)
- University of Stavanger,Stavanger University Hospital
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- Kramberger, M. G. (author)
- University Medical Centre Ljubljana
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- Zetterberg, Henrik, 1973 (author)
- University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,University College London
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- Mollenhauer, B. (author)
- Paracelsus-Elena-Klinik Kassel,University Medical Center Göttingen
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- Boada, M. (author)
- Barcelona Alzheimer Treatment & Research Center
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- Aarsland, D. (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2016-06-14
- 2016
- English.
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In: Movement Disorders. - : Wiley. - 0885-3185 .- 1531-8257. ; 31:8, s. 1203-1208
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Abstract
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- IntroductionAlzheimer's disease pathologies are common in dementia with Lewy bodies, but their clinical relevance is not clear. CSF biomarkers amyloid beta 1-42, total tau, and tau phosphorylated at threonine 181 reflect Alzheimer's disease neuropathology antemortem. In PD, low CSF amyloid beta 1-42 predict long-term cognitive decline, but little is known about these biomarkers as predictors for cognitive decline in Lewy body dementia. The aim of this study was to assess whether Alzheimer's disease CSF biomarkers predict cognitive decline in Lewy body dementia. MethodsFrom a large European dementia with Lewy bodies multicenter study, we analyzed baseline Alzheimer's disease CSF biomarkers and serial MMSE (baseline and 1- and 2-year follow-up) in 100 patients with Lewy body dementia. Linear mixed-effects analyses, adjusted for sex, age, baseline MMSE, and education, were performed to model the association between CSF biomarkers and rate of cognitive decline measured with MMSE. An Alzheimer's disease CSF profile was defined as pathological amyloid beta 1-42 plus pathological total tau or phosphorylated tau. ResultsThe Alzheimer's disease CSF profile, and pathological levels of amyloid beta 1-42, were associated with a more rapid decline in MMSE (2.2 [P < 0.05] and 2.9 points difference [P < 0.01], respectively). Higher total tau values showed a trend toward association without statistical significance (2.0 points difference; P = 0.064), whereas phosphorylated tau was not associated with decline. ConclusionsReduced levels of CSF amyloid beta 1-42 were associated with more rapid cognitive decline in Lewy body dementia patients. Future prospective studies should include larger samples, centralized CSF analyses, longer follow-up, and biomarker-pathology correlation. (c) 2016 International Parkinson and Movement Disorder Society
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Lewy body dementia
- CSF biomarkers
- cognitive decline
- mini-mental-state
- csf amyloid-beta
- parkinsons-disease
- differential-diagnosis
- alpha-synuclein
- tau-protein
- a-beta
- bodies
- pathology
- performance
- Neurosciences & Neurology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Abdelnour, C.
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van Steenoven, I ...
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Londos, Elisabet
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Blanc, F.
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Auestad, B.
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Kramberger, M. G ...
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show more...
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Zetterberg, Henr ...
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Mollenhauer, B.
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Boada, M.
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Aarsland, D.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Movement Disorde ...
- By the university
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University of Gothenburg
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Lund University
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Karolinska Institutet