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  • Campbell, PJUniv Cambridge, Dept Haematol, Cambridge, England;Wellcome Sanger Inst, Hinxton, England,Wellcome Trust Sanger Institute (author)

Pan-cancer analysis of whole genomes

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-02-05
  • Springer Science and Business Media LLC,2020

Numbers

  • LIBRIS-ID:oai:prod.swepub.kib.ki.se:143672104
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143672104URI
  • https://doi.org/10.1038/s41586-020-1969-6DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-412970URI
  • https://lup.lub.lu.se/record/7c1e51e0-36fe-44c6-bf19-5b3dc35b978eURI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • For complete list of authors see http://dx.doi.org/10.1038/s41586-020-1969-6
  • Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1–3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10–18.

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  • Getz, G (author)
  • Korbel, JO (author)
  • Stuart, JM (author)
  • Jennings, JLKarolinska Institutet (author)
  • Stein, LD (author)
  • Perry, MD (author)
  • Nahal-Bose, HK (author)
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  • Li, CH (author)
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  • Shelton, T (author)
  • Shi, Y (author)
  • Shih, J (author)
  • Shmulevich, I (author)
  • Shriver, C (author)
  • Signoretti, S (author)
  • Simons, J (author)
  • Singer, S (author)
  • Sipahimalani, P (author)
  • Skelly, TJ (author)
  • McCune, KS (author)
  • Socci, ND (author)
  • Soloway, MG (author)
  • Sood, AK (author)
  • Tam, A (author)
  • Tan, D (author)
  • Tarnuzzer, R (author)
  • Thiessen, N (author)
  • Thompson, RH (author)
  • Thorne, LB (author)
  • Tsao, M (author)
  • Umbricht, C (author)
  • Van Den Berg, DJ (author)
  • Van Meir, EG (author)
  • Veluvolu, U (author)
  • Voet, D (author)
  • Wang, L (author)
  • Weinberger, P (author)
  • Weisenberger, DJ (author)
  • Wigle, D (author)
  • Wilkerson, MD (author)
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  • Wong, W (author)
  • Xi, L (author)
  • Yau, C (author)
  • Zhang, H (author)
  • Zhang, H (author)
  • Zhang, J (author)
  • Univ Cambridge, Dept Haematol, Cambridge, England;Wellcome Sanger Inst, Hinxton, EnglandWellcome Trust Sanger Institute (creator_code:org_t)

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Ogden, C
Rowe, EW
Shah, NC
Thomas, S
Thompson, A
Verrill, C
Visakorpi, T
Warren, AY
Whitaker, HC
Zhang, H
van As, N
Eeles, RA
Abeshouse, A
Agrawal, N
Akbani, R
Al Ahmadie, H
Albert, M
Aldape, K
Ally, A
Appelbaum, EL
Armenia, J
Asa, S
Auman, JT
Balasundaram, M
Balu, S
Barnholtz-Sloan, ...
Bathe, OF
Baylin, SB
Benz, C
Berchuck, A
Berrios, M
Bigner, D
Birrer, M
Bodenheimer, T
Boice, L
Bootwalla, MS
Bosenberg, M
Bowlby, R
Boyd, J
Broaddus, RR
Brock, M
Brooks, D
Bullman, S
Caesar-Johnson, ...
Carey, TE
Carlsen, R
Cerfolio, R
Chandan, VS
Chen, HW
Cherniack, AD
Chien, J
Cho, J
Chuah, E
Cibulskis, C
Cope, L
Cordes, MG
Curley, E
Czerniak, B
Danilova, L
Davis, IJ
Defreitas, T
Demchok, JA
Dhalla, N
Dhir, R
Doddapaneni, H
El-Naggar, A
Felau, I
Ferguson, ML
Finocchiaro, G
Fong, KM
Frazer, S
Friedman, W
Fronick, CC
Fulton, LA
Gabriel, SB
Gao, J
Gehlenborg, N
Gershenwald, JE
Ghossein, R
Giama, NH
Gibbs, RA
Gomez, C
Govindan, R
Hayes, DN
Hegde, AM
Heiman, D
Heins, Z
Hepperla, AJ
Holbrook, A
Holt, RA
Hoyle, AP
Hruban, RH
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Huang, M
Huntsman, D
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Jayaseelan, JC
Jefferys, SR
Jones, CD
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Juhl, H
Kang, KJ
Karlan, B
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Kebebew, E
Kim, HK
Korchina, V
Kundra, R
Lai, PH
Lander, E
Le, X
Levine, DA
Lewis, L
Ley, T
Li, HI
Lin, P
Linehan, WM
Liu, FF
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Ma, Y
Maglinte, DT
Mardis, ER
Marks, J
Marra, MA
Matthew, TJ
Mayo, M
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Meier, SR
Meng, S
Mieczkowski, PA
Mikkelsen, T
Miller, CA
Mills, GB
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Morrison, C
Mose, LE
Moser, CD
Mungall, AJ
Mungall, K
Mutch, D
Muzny, DM
Myers, J
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O'Neill, BP
Ochoa, A
Parker, JS
Pass, H
Pastore, A
Pennell, NA
Perou, CM
Petrelli, N
Potapova, O
Rader, JS
Ramalingam, S
Rathmell, WK
Reuter, V
Reynolds, SM
Ringel, M
Roach, J
Roberts, LR
Robertson, AG
Sadeghi, S
Saller, C
Sanchez-Vega, F
Schadendorf, D
Schein, JE
Schmidt, HK
Schultz, N
Seethala, R
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Shelton, T
Shi, Y
Shih, J
Shmulevich, I
Shriver, C
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Simons, J
Singer, S
Sipahimalani, P
Skelly, TJ
McCune, KS
Socci, ND
Soloway, MG
Sood, AK
Tam, A
Tan, D
Tarnuzzer, R
Thiessen, N
Thompson, RH
Thorne, LB
Tsao, M
Umbricht, C
Van Den Berg, DJ
Van Meir, EG
Veluvolu, U
Voet, D
Wang, L
Weinberger, P
Weisenberger, DJ
Wigle, D
Wilkerson, MD
Wilson, RK
Winterhoff, B
Wiznerowicz, M
Wong, T
Wong, W
Xi, L
Yau, C
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About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Medical Genetics
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Clinical Medicin ...
and Cancer and Oncol ...
Articles in the publication
Nature
By the university
Karolinska Institutet
Uppsala University
Lund University

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