Repositioning of the global epicentre of non-optimal cholesterol

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Taddei, CImperial College London, United Kingdom,Imperial Coll London, London, England (author)

Repositioning of the global epicentre of non-optimal cholesterol

Article/chapterEnglish2020

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2020-06-03
Springer Science and Business Media LLC,2020

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LIBRIS-ID:oai:prod.swepub.kib.ki.se:144522582
http://kipublications.ki.se/Default.aspx?queryparsed=id:144522582URI
https://doi.org/10.1038/s41586-020-2338-1DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172136URI
https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-18680URI
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-421556URI
https://lup.lub.lu.se/record/4d44cfea-dddf-4184-88fb-63dc4a6e1761URI
https://gup.ub.gu.se/publication/295847URI

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Language:English
Summary in:English

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CC BY 4.0NCD Risk Factor Collaboration (NCD-RisC)
For complete list of authors see http://dx.doi.org/10.1038/s41586-020-2338-1
High blood cholesterol is typically considered a feature of wealthy western countries1,2. However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol—which is a marker of cardiovascular risk—changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million–4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Omvårdnad hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Nursing hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Allmänmedicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine General Practice hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine hsv//eng
Individual and Society VIDSOC
high density lipoprotein cholesterol
blood
chemical compound
lipid
nutrition
protein
public health
adult
age distribution
Article
Australia and New Zealand
brain ischemia
cardiovascular mortality
cardiovascular risk
cholesterol blood level
controlled study
disease burden
Europe
female
geographic distribution
high income country
human
lipid analysis
lipid blood level
low income country
male
middle income country
mortality rate
North America
population research
priority journal
sex ratio
Southeast Asia
trend study
young adult
Arctic
Australasia
Greenland
Adolescent
Adult
Aged
80 and over
Bayes Theorem
Cholesterol
HDL
LDL
Female
Humans
Hypercholesterolemia
epidemiology
Internationality
Male
Middle Aged
Myocardial Ischemia
Stroke
Triglycerides
Young Adult

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