Continuity of Genetic Risk for Aggressive Behavior Across the Life-Course

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We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12–70 years, Australia: 16–73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a ‘rolling weights’ model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41–70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.

Ingår i:Behavior genetics: Springer Science and Business Media LLC51:5, s. 592-6061573-32970001-8244

Av författaren/redakt...: van der Laan, CM; Morosoli-Garcia, ...; van de Weijer, S ...; Colodro-Conde, L; Lupton, MK; Mitchell, BL; visa fler...; McAloney, K; Parker, R; Burns, JM; Hickie, IB; Pool, R; Hottenga, JJ; Martin, NG; Medland, SE; Nivard, MG; Boomsma, DI; visa färre...

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