Tyck till om SwePub Sök här!
WFRF:(Hagg E)
Search: WFRF:(Hagg E) > Peer-reviewed > Medical and Health Sciences > Kim Y. > Within-sibship geno...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Howe, LJUniv Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.;Bristol NIHR Biomed Res Ctr, Bristol, Avon, England (author)
Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-05-09
- Springer Science and Business Media LLC,2022
Numbers
- LIBRIS-ID:oai:prod.swepub.kib.ki.se:149606175
- http://kipublications.ki.se/Default.aspx?queryparsed=id:149606175URI
- https://doi.org/10.1038/s41588-022-01062-7DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-205263URI
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-476116URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Nivard, MGVrije Univ, Netherlands Twin Register, Dept Biol Psychol, Amsterdam, Netherlands,Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.;Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London, England (author)
- Morris, TTUniv Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England,Univ Bergen, Dept Global Publ Hlth & Primary Care, Bergen, Norway (author)
- Hansen, AFNorwegian Univ Sci & Technol, NTNU, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway (author)
- Rasheed, HUniv Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Norwegian Univ Sci & Technol, NTNU, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway (author)
- Cho, YSUniv Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England (author)
- Chittoor, GGeisinger Hlth, Dept Populat Hlth Sci, Danville, PA USA,Vrije Univ, Netherlands Twin Register, Dept Biol Psychol, Amsterdam, Netherlands.;Amsterdam UMC, Amsterdam Publ Hlth Res Inst, Amsterdam, Netherlands (author)
- Ahlskog, RafaelUppsala universitet,Statsvetenskapliga institutionen(Swepub:uu)rafah888 (author)
- Lind, PAQIMR Berghofer Med Res Inst, Psychiat Genet, Brisbane, Qld, Australia.;Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld, Australia.;Univ Queensland, Fac Med, Brisbane, Qld, Australia (author)
- Palviainen, TUniv Helsinki, Inst Mol Med FIMM, Helsinki, Finland (author)
- van der Zee, MDVrije Univ, Netherlands Twin Register, Dept Biol Psychol, Amsterdam, Netherlands,Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England (author)
- Cheesman, RUniv Oslo, PROMENTA Res Ctr, Dept Psychol, Oslo, Norway.;Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England (author)
- Mangino, MUniv Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA,Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA.;Univ Colorado, Dept Ecol & Evolutionary Biol, Boulder, CO 80309 USA,Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.;Norwegian Univ Sci & Technol, NTNU, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway,Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Queensland, Diamantina Inst, Brisbane, Qld, Australia.;Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia (author)
- Wang, YZKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
- Li, SUniv Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia,Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA (author)
- Klaric, LUniv Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland (author)
- Ratliff, SM (author)
- Bielak, LFUniv Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA (author)
- Nygaard, MUniv Southern Denmark, Dept Publ Hlth, Danish Twin Registry, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark (author)
- Giannelis, AUniv Minnesota, Dept Psychol, Minneapolis, MN USA (author)
- Willoughby, EAUniv Minnesota, Dept Psychol, Minneapolis, MN USA (author)
- Reynolds, CAUniv Calif Riverside, Dept Psychol, Riverside, CA 92521 USA,Univ Edinburgh, Western Gen Hosp, Inst Genet & Canc, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland (author)
- Balbona, JVUniv Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA (author)
- Andreassen, OAUniv Oslo, NORMENT Ctr, Oslo, Norway.;Oslo Univ Hosp, Div Mental Hlth & Addict, Oslo, Norway (author)
- Ask, HNorwegian Inst Publ Hlth, Dept Mental Disorders, Oslo, Norway (author)
- Baras, ARegeneron Genet Ctr, Tarrytown, NY USA (author)
- Bauer, CRBioMarin Pharmaceut Inc, Novato, CA USA.;Geisinger Hlth, Biomed & Translat Informat, Danville, PA USA (author)
- Boomsma, DIVrije Univ, Netherlands Twin Register, Dept Biol Psychol, Amsterdam, Netherlands.;Amsterdam Publ Hlth APH & Amsterdam Reprod & Dev, Amsterdam, Netherlands (author)
- Campbell, A (author)
- Campbell, HUniv Edinburgh, Usher Inst, Ctr Global Hlth, Edinburgh, Midlothian, Scotland (author)
- Chen, ZMUniv Oxford, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, MRC Populat Hlth Res Unit, Oxford, England (author)
- Christofidou, PKings Coll London, Dept Twin Res & Genet Epidemiol, London, England (author)
- Corfield, ENorwegian Inst Publ Hlth, Dept Mental Disorders, Oslo, Norway.;Lovisenberg Diaconal Hosp, Nic Waals Inst, Oslo, Norway (author)
- Dahm, CCAarhus Univ, Dept Publ Hlth, Aarhus, Denmark (author)
- Dokuru, DRUniv Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA (author)
- Evans, LM (author)
- de Geus, EJC (author)
- Giddaluru, SUniv Oslo, Inst Hlth & Soc, Oslo, Norway.;Norwegian Inst Publ Hlth, Oslo, Norway (author)
- Gordon, SDQIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia (author)
- Harden, KPUniv Texas Austin, Dept Psychol, Austin, TX 78712 USA.;Univ Texas Austin, Populat Res Ctr, Austin, TX 78712 USA (author)
- Hill, WDUniv Edinburgh, Dept Psychol, Lothian Birth Cohorts Grp, Edinburgh, Midlothian, Scotland (author)
- Hughes, AUniv Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland (author)
- Kerr, SMKarolinska Institutet (author)
- Kim, YUniv Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland (author)
- Kweon, HUniv Colorado, Inst Behav Genet, Boulder, CO 80309 USA.;Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia,Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA (author)
- Latvala, AVrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands (author)
- Lawlor, DAUniv Helsinki, Fac Social Sci, Inst Criminol & Legal Policy, Helsinki, Finland (author)
- Li, LM (author)
- Lin, KPeking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China (author)
- Magnus, P (author)
- Magnusson, PKEKarolinska Institutet,Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway (author)
- Mallard, TTKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
- Martikainen, PekkaStockholms universitet,Centrum för forskning om ojämlikhet i hälsa (CHESS),University of Helsinki, Finland; The Max Planck Institute for Demographic Research, Germany,Univ Texas Austin, Dept Psychol, Austin, TX 78712 USA.;Univ Texas Austin, Populat Res Ctr, Austin, TX 78712 USA(Swepub:su)pemar (author)
- Mills, MCUniv Helsinki, Fac Social Sci, Populat Res Unit, Helsinki, Finland.;Max Planck Inst Demog Res, Rostock, Germany.;Stockholm Univ, Dept Publ Hlth Sci, Stockholm, Sweden (author)
- Njolstad, PRUniv Oxford, Leverhulme Ctr Demog Sci, Oxford, England,Kings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England (author)
- Overton, JDUniv Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Children & Youth Clin, Bergen, Norway (author)
- Pedersen, NLKarolinska Institutet,Regeneron Genet Ctr, Tarrytown, NY USA (author)
- Porteous, DJKarolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
- Reid, JUniv Edinburgh, Western Gen Hosp, Inst Genet & Canc, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland. (author)
- Silventoinen, KKarolinska Institutet,Regeneron Genet Ctr, Tarrytown, NY USA (author)
- Southey, MCUniv Helsinki, Fac Social Sci, Populat Res Unit, Helsinki, Finland (author)
- Stoltenberg, CMonash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.;Univ Melbourne, Melbourne Med Sch, Dept Clin Pathol, Melbourne, Vic, Australia.;Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia (author)
- Tucker-Drob, EM (author)
- Wright, MJUniv Texas Austin, Dept Psychol, Austin, TX 78712 USA.;Univ Texas Austin, Populat Res Ctr, Austin, TX 78712 USA (author)
- Kweon, H (author)
- Hewitt, JKUniv Helsinki, Inst Mol Med FIMM, Helsinki, Finland (author)
- Keller, MCUniv Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA (author)
- Stallings, MCUniv Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA.;Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA (author)
- Lee, JJUniv Minnesota, Dept Psychol, Minneapolis, MN USA,Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic, Australia (author)
- Christensen, KUniv Southern Denmark, Dept Publ Hlth, Danish Twin Registry, Odense, Denmark.;Odense Univ Hosp, Dept Clin Genet, Odense, Denmark.;Odense Univ Hosp, Dept Clin Biochem & Pharmacol, Odense, Denmark (author)
- Kardia, SLR (author)
- Peyser, PAUniv Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA (author)
- Smith, JAUniv Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.;Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI USA (author)
- Wilson, JFUniv Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland (author)
- Hopper, JL (author)
- Hagg, SKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden (author)
- Spector, TDKings Coll London, Dept Twin Res & Genet Epidemiol, London, England (author)
- Pingault, JBKings Coll London, Inst Psychiat Psychol & Neurosci, Social Genet & Dev Psychiat Ctr, London, England.;UCL, Dept Clin Educ & Hlth Psychol, London, England,Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Norwegian Univ Sci & Technol, NTNU, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway.;Norwegian Univ Sci & Technol, NTNU, HUNT Res Ctr, Dept Publ Hlth & Nursing, Levanger, Norway (author)
- Plomin, R (author)
- Havdahl, AUniv Oslo, PROMENTA Res Ctr, Dept Psychol, Oslo, Norway.;Norwegian Inst Publ Hlth, Dept Mental Disorders, Oslo, Norway.;Lovisenberg Diaconal Hosp, Nic Waals Inst, Oslo, Norway (author)
- Bartels, MVrije Univ, Netherlands Twin Register, Dept Biol Psychol, Amsterdam, Netherlands (author)
- Martin, NGQIMR Berghofer Med Res Inst, Dept Genet & Computat Biol, Brisbane, Qld, Australia (author)
- Oskarsson, Sven,1971-Uppsala universitet,Statsvetenskapliga institutionen(Swepub:uu)sos20331 (author)
- Justice, AEGeisinger Hlth, Dept Populat Hlth Sci, Danville, PA USA (author)
- Millwood, IYUniv Oxford, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, MRC Populat Hlth Res Unit, Oxford, England (author)
- Hveem, KNorwegian Univ Sci & Technol, NTNU, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway.;Norwegian Univ Sci & Technol, NTNU, HUNT Res Ctr, Dept Publ Hlth & Nursing, Levanger, Norway (author)
- Naess, OUniv Oslo, Inst Hlth & Soc, Oslo, Norway.;Norwegian Inst Publ Hlth, Oslo, Norway (author)
- Willer, CJNorwegian Univ Sci & Technol, NTNU, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway.;Univ Michigan, Dept Internal Med Cardiol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI USA (author)
- Asvold, BONorwegian Univ Sci & Technol, NTNU, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Trondheim, Norway.;Norwegian Univ Sci & Technol, NTNU, HUNT Res Ctr, Dept Publ Hlth & Nursing, Levanger, Norway.;Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Endocrinol, Clin Med, Trondheim, Norway (author)
- Koellinger, PDVrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands.;Univ Wisconsin, La Follette Sch Publ Affairs, Madison, WI USA (author)
- Kaprio, J (author)
- Medland, SEQIMR Berghofer Med Res Inst, Psychiat Genet, Brisbane, Qld, Australia.;Univ Queensland, Fac Med, Brisbane, Qld, Australia.;Univ Queensland, Sch Psychol, Brisbane, Qld, Australia (author)
- Walters, RGUniv Oxford, Nuffield Dept Populat Hlth, Oxford, England.;Univ Oxford, MRC Populat Hlth Res Unit, Oxford, England (author)
- Benjamin, DJUniv Calif Los Angeles, Anderson Sch Management, Los Angeles, CA USA.;Univ Calif Los Angeles, David Geffen Sch Med, Gonda Goldschmied Neurosci & Genet Res Ctr, Dept Human Genet, Los Angeles, CA 90095 USA.;Natl Bur Econ Res, Cambridge, MA 02138 USA (author)
- Turley, PUniv Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90007 USA.;Univ Southern Calif, Dept Econ, Los Angeles, CA 90007 USA (author)
- Evans, DM (author)
- Smith, GDUniv Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England (author)
- Hayward, CUniv Edinburgh, Western Gen Hosp, Inst Genet & Canc, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland (author)
- Brumpton, B (author)
- Hemani, GUniv Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England (author)
- Davies, NM (author)
- Univ Bristol, Med Res Council, Integrat Epidemiol Unit, Bristol, Avon, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.;Bristol NIHR Biomed Res Ctr, Bristol, Avon, EnglandVrije Univ, Netherlands Twin Register, Dept Biol Psychol, Amsterdam, Netherlands (creator_code:org_t)
Related titles
- In:Nature genetics: Springer Science and Business Media LLC54:65, s. 581-+1546-17181061-4036
Internet link
- https://doi.org/10.1038/s41588-022-01062-7Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1665944/FULLTEXT01.pdffulltext:print
- http://kipublications.ki.se/Default.aspx?queryparsed=id:149606175
- https://doi.org/10.1038/s41588-022-01062-7
- https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-205263
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-476116
Find in a library
- Nature genetics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Howe, LJ
- Nivard, MG
- Morris, TT
- Hansen, AF
- Rasheed, H
- Cho, YS
- show more...
- Chittoor, G
- Ahlskog, Rafael
- Lind, PA
- Palviainen, T
- van der Zee, MD
- Cheesman, R
- Mangino, M
- Wang, YZ
- Li, S
- Klaric, L
- Ratliff, SM
- Bielak, LF
- Nygaard, M
- Giannelis, A
- Willoughby, EA
- Reynolds, CA
- Balbona, JV
- Andreassen, OA
- Ask, H
- Baras, A
- Bauer, CR
- Boomsma, DI
- Campbell, A
- Campbell, H
- Chen, ZM
- Christofidou, P
- Corfield, E
- Dahm, CC
- Dokuru, DR
- Evans, LM
- de Geus, EJC
- Giddaluru, S
- Gordon, SD
- Harden, KP
- Hill, WD
- Hughes, A
- Kerr, SM
- Kim, Y
- Kweon, H
- Latvala, A
- Lawlor, DA
- Li, LM
- Lin, K
- Magnus, P
- Magnusson, PKE
- Mallard, TT
- Martikainen, Pek ...
- Mills, MC
- Njolstad, PR
- Overton, JD
- Pedersen, NL
- Porteous, DJ
- Reid, J
- Silventoinen, K
- Southey, MC
- Stoltenberg, C
- Tucker-Drob, EM
- Wright, MJ
- Hewitt, JK
- Keller, MC
- Stallings, MC
- Lee, JJ
- Christensen, K
- Kardia, SLR
- Peyser, PA
- Smith, JA
- Wilson, JF
- Hopper, JL
- Hagg, S
- Spector, TD
- Pingault, JB
- Plomin, R
- Havdahl, A
- Bartels, M
- Martin, NG
- Oskarsson, Sven, ...
- Justice, AE
- Millwood, IY
- Hveem, K
- Naess, O
- Willer, CJ
- Asvold, BO
- Koellinger, PD
- Kaprio, J
- Medland, SE
- Walters, RG
- Benjamin, DJ
- Turley, P
- Evans, DM
- Smith, GD
- Hayward, C
- Brumpton, B
- Hemani, G
- Davies, NM
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- Nature genetics
- By the university
- Karolinska Institutet
- Stockholm University
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
