Immune system alteration in response to two consecutive soccer games.

• AIM: Changes in leucocyte and monocyte subpopulations were investigated in 10 elite male soccer players aged 16-19 years. The purpose was to perform a descriptive study of immunological alterations in elite soccer players in response to two consecutive games separated by 20 h. It was hypothesized that in response to two games the players would show signs of short-term immunosuppression. METHODS: Blood samples were taken before the first soccer game, immediately after the second game and after 6, 24, 48 and 72 h. Cell surface antigens, testosterone and cortisol were investigated. RESULTS: During the first 6 h after the second game there was a significant increase in number of circulating neutrophils, mature (CD20+ CD5+) B cells and CD4/CD8 ratio. A significant decrease was observed in the number of natural killer (NK) cells, monocytes and adhesion on lymphocytes and monocytes. In a delayed phase, 48 h after the second game the expression of both adhesion and signalling molecules increased on lymphocytes and monocytes. Changes in adhesion and signalling molecules at 48 h correlated negatively to the subjects VO2max, suggesting larger immunological response to similar exercise in subjects with lower aerobic exercise capacity. CONCLUSION: In response to competitive soccer exercise some immunological variables are enhanced while others are depressed. Observed changes may serve a purpose in adaptation to exercise by signalling via adhesion.

Nyckelord

Adolescent

Adult

Antigens; CD/immunology

B-Lymphocytes/immunology

CD4-CD8 Ratio/methods

Cell Adhesion/immunology

Cell Adhesion Molecules/immunology

Exercise/physiology

Flow Cytometry/methods

Football/*physiology

Humans

Hydrocortisone/blood

Killer Cells; Natural/immunology

Leukocyte Count

Leukocytes/*immunology

Male

Monocytes/immunology

Neutrophils/immunology

Oxygen Consumption/immunology

Phenotype

Signal Transduction/immunology

T-Lymphocytes/immunology

Testosterone/blood

MEDICINE

Publikations- och innehållstyp

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