A molecular mechanism for choosing alcohol over an alternative reward

Tyck till om SwePub Sök här!

Barbier, Estelle (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten

Dulman, R. S. (author): Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois, Chicago, IL 60612, USA

Licheri, Valentina (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Göteborg, 413 90 Göteborg, Sweden

Augier, Gaëlle (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten

Domi, Esi (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten

Barchiesi, Riccardo (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten

Farris, S. (author): The Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712, USA

Nätt, Daniel (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten

Mayfield, R. D. (author): The Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, TX 78712, USA

Adermark, Louise, 1974 (author): Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Göteborg, 413 90 Göteborg, Sweden

Heilig, Markus (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken

Augier, Eric (author): Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten

(creator_code:org_t)

American Association for the Advancement of Science (AAAS), 2018
2018
English.
In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 360:6395

Related links:: https://gup.ub.gu.se...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which similar to 15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the g-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder.

By the author/editor: Barbier, Estelle; Dulman, R. S.; Licheri, Valenti ...; Augier, Gaëlle; Domi, Esi; Barchiesi, Ricca ...; show more...; Farris, S.; Nätt, Daniel; Mayfield, R. D.; Adermark, Louise ...; Heilig, Markus; Augier, Eric; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.