SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:oru-44592"
 

Sökning: onr:"swepub:oai:DiVA.org:oru-44592" > Risk for gastric ca...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004238naa a2200421 4500
001oai:DiVA.org:oru-44592
003SwePub
008150511s2000 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:1928538
009oai:DiVA.org:uu-54774
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-445922 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:19285382 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-547742 URI
040 a (SwePub)orud (SwePub)kid (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Akre [Fall], Katja,d 1971-u Uppsala universitet,Karolinska Institutet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)kafl
2451 0a Risk for gastric cancer after antibiotic prophylaxis in patients undergoing hip replacement
264 1a Birmingham, USA :b American Asoociation for Cancer Research,c 2000
338 a print2 rdacarrier
520 a Despite strong evidence of an association between Helicobacter pylori and gastric cancer, the benefit of eradicating H. pylori infection is unknown. Our aim was to test the hypothesis that exposure to high doses of antibiotics reduces risk for gastric cancer via possible eradication of H. pylori We conducted a nationwide case-control study nested in a cohort of 39,154 patients who underwent hip replacement surgery between 1965 and 1983. Such patients frequently receive prophylactic antibiotic treatment. During follow-up through 1989, we identified 189 incident cases of gastric cancer. For each case, three controls were selected from the cohort. Exposure data were abstracted from hospital records. Blood samples from a separate cohort undergoing hip replacement surgery were analyzed for anti-H. pylori IgG before and after surgery. Both long-term antibiotic treatment before surgery [odds ratio (OR), 0.3; 95% confidence interval (CI), 0.1-0.7] and prophylactic antibiotic treatment (OR, 0.7; 95% CI, 0.5-1.1) conferred a reduction in gastric cancer risk. The reduction appeared stronger after 5 years (OR, 0.6; 95% CI, 0.3-1.2) than during shorter follow-up after hip replacement (OR, 0.8; 95% CI, 0.4-1.7). There was an apparent decrease in risk with increasing body weight-adjusted doses of antibiotics (P = 0.13). However, the rate of H. pylori antibody disappearance was not strikingly higher in the cohort of patients undergoing hip replacement than in a control cohort. Our findings provide indirect support for the hypothesis that treatment with antibiotics at a relatively advanced age reduces the risk of gastric cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Signorello, Lisa B.u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut
7001 a Engstrand, Larsu Uppsala universitet,Karolinska Institutet,Institutionen för medicinska vetenskaper4 aut
7001 a Bergström, Reinholdu Uppsala universitet,Institutionen för medicinska vetenskaper4 aut
7001 a Larsson, Suneu Uppsala universitet,Institutionen för kirurgiska vetenskaper,Orthopaedics4 aut
7001 a Eriksson, Bengt I.u Uppsala universitet,Institutionen för medicinska vetenskaper4 aut
7001 a Nyrén, Olofu Uppsala universitet,Karolinska Institutet,Institutionen för medicinska vetenskaper4 aut
7102 a Karolinska Institutetb Institutionen för medicinska vetenskaper4 org
7730 t Cancer Researchd Birmingham, USA : American Asoociation for Cancer Researchg 60, s. 6376-q 60:22<6376-80x 0008-5472x 1538-7445
7730 t Cancer Resd Birmingham, USA : American Asoociation for Cancer Researchg 60, s. 6376-q 60<6376-
8564 u https://aacrjournals.org/cancerres/article/60/22/6376/506877/Risk-for-Gastric-Cancer-after-Antibioticy Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-44592
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:1928538
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-54774

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy