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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06189naa a2200541 4500 | |
| 001 | oai:gup.ub.gu.se/244478 | |
| 003 | SwePub | |
| 008 | 240410s2017 | |||||||||||000 ||eng| | |
| 009 | oai:research.chalmers.se:1d63553d-3231-4819-a414-09446ffe9e69 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2444782 URI |
| 024 | 7 | a https://doi.org/10.2967/jnumed.116.1769582 DOI |
| 024 | 7 | a https://research.chalmers.se/publication/2484852 URI |
| 040 | a (SwePub)gud (SwePub)cth | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Langen, Brittau Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg,Chalmers tekniska högskola,Chalmers University of Technology4 aut0 (Swepub:cth)xbritl |
| 245 | 1 0 | a Microarray Studies on 211At Administration in BALB/c Nude Mice Indicate Systemic Effects on Transcriptional Regulation in Non-Thyroid Tissues |
| 264 | c 2016-10-20 | |
| 264 | 1 | b Society of Nuclear Medicine,c 2017 |
| 520 | a Introduction: Targeted α-therapy is a promising treatment option for various types of malignant tumors. Radiolabeled cancer-seeking agents, however, undergo degradation resulting in a certain percentage of free radionuclide in the body. The radiohalogen 211At accumulates in various tissues with specifically high uptake in the thyroid. When normal thyroid function is disturbed due to ionizing radiation (IR) exposure, deleterious effects can occur in tissues that depend on thyroid hormone (TH) regulation for normal physiological function. However, knowledge of systemic effects is still rudimentary. We previously reported similarities in transcriptomic regulation between the thyroid and other tissues despite large differences in absorbed dose from 211At (Langen et al. JNM, 2013). Here, we present supportive evidence on systemic effects after 211At administration. Methods: Expression microarray data from kidney cortex and medulla, liver, lungs, and spleen were used from previous studies where mice were i.v. injected with 0.064–42 kBq 211At and killed after 24 h, or injected with 1.7 kBq 211At and killed after 1, 6, or 168 h. Controls were mock-treated and killed after 24 h. Literature-based gene signatures were used to evaluate the relative impact from IR- or TH-induced regulation. Thyroid- and TH-associated upstream regulators as well as thyroid-related diseases and functions were generated using functional analysis software. Results: Responses in IR- or TH-associated gene signatures were tissue-specific, varied over time, and the relative impact of each gene signature differed between the investigated tissues. The liver showed a clear dominance of TH-responding genes. In the kidney cortex, kidney medulla, and lungs, the TH-associated signature was detected to at least similar extent as the IR-associated signature. The spleen was the single tissue showing regulation of only IR-associated signature genes. Various thyroid-associated diseases and functions were inferred from the data: L-triiodothyronine, TH, TH receptor, and triiodothyronine (reverse) were inferred as upstream-regulators with differences in incidence and strength of regulation depending on tissue type. Conclusion: These findings indicate that transcriptional regulation in various non-thyroid tissues was–in part–induced by thyroid (hormone)-dependent signaling. Consideration of the systemic context between tissues could contribute to normal tissue risk assessment and planning of remedial measures. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng |
| 650 | 7 | a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Medicinteknik0 (SwePub)2062 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Medical Engineering0 (SwePub)2062 hsv//eng |
| 653 | a Molecular Biology | |
| 653 | a Radiobiology/Dosimetry | |
| 653 | a Radionuclide Therapy | |
| 653 | a astatine-211 | |
| 653 | a normal tissue response | |
| 653 | a radiogenomics | |
| 653 | a radionuclide therapy | |
| 653 | a systemic effects | |
| 653 | a Radionuclide therapy | |
| 700 | 1 | a Rudqvist, Nilsu Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg4 aut0 (Swepub:gu)xrudni |
| 700 | 1 | a Helou, Khalil,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för onkologi,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Oncology,University of Gothenburg4 aut0 (Swepub:gu)xhelkh |
| 700 | 1 | a Forssell-Aronsson, Eva,d 1961u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för radiofysik,Sahlgrenska Cancer Center,Institute of Clinical Sciences, Department of Radiation Physics,University of Gothenburg4 aut0 (Swepub:gu)xforev |
| 710 | 2 | a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för radiofysik4 org |
| 773 | 0 | t Journal of Nuclear Medicined : Society of Nuclear Medicineg 58:2, s. 346-353q 58:2<346-353x 0161-5505x 2159-662X |
| 856 | 4 | u http://jnm.snmjournals.org/content/58/2/346.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/244478 |
| 856 | 4 8 | u https://doi.org/10.2967/jnumed.116.176958 |
| 856 | 4 8 | u https://research.chalmers.se/publication/248485 |
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