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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 06863naa a2201429 4500 | |
| 001 | oai:gup.ub.gu.se/281582 | |
| 003 | SwePub | |
| 008 | 240910s2019 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:6f3d41c8-ef68-4340-ad12-8375abfb9791 | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2815822 URI |
| 024 | 7 | a https://doi.org/10.1016/j.nbd.2019.04.0042 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/6f3d41c8-ef68-4340-ad12-8375abfb97912 URI |
| 040 | a (SwePub)gud (SwePub)lu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Guerreiro, R.u University College London4 aut |
| 245 | 1 0 | a Heritability and genetic variance of dementia with Lewy bodies |
| 264 | 1 | b Elsevier BV,c 2019 |
| 520 | a Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established that a substantial portion of the genetic heritable component of complex traits is not captured by genome-wide significant SNPs. To overcome this issue, we have estimated the proportion of phenotypic variance explained by genetic variability (SNP heritability) in DLB using a method that is unbiased by allele frequency or linkage disequilibrium properties of the underlying variants. This shows that the heritability of DLB is nearly twice as high as previous estimates based on common variants only (31% vs 59.9%). We also determine the amount of phenotypic variance in DLB that can be explained by recent polygenic risk scores from either Parkinson's disease (PD) or Alzheimer's disease (AD), and show that, despite being highly significant, they explain a low amount of variance. Additionally, to identify pleiotropic events that might improve our understanding of the disease, we performed genetic correlation analyses of DLB with over 200 diseases and biomedically relevant traits. Our data shows that DLB has a positive correlation with education phenotypes, which is opposite to what occurs in AD. Overall, our data suggests that novel genetic risk factors for DLB should be identified by larger GWAS and these are likely to be independent from known AD and PD risk variants. © 2019 Elsevier Inc. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a Dementia | |
| 653 | a Genetic correlation | |
| 653 | a Genetic variance | |
| 653 | a Lewy bodies | |
| 653 | a Alzheimer disease | |
| 653 | a anthropometry | |
| 653 | a Article | |
| 653 | a cognition | |
| 653 | a diffuse Lewy body disease | |
| 653 | a education | |
| 653 | a gene frequency | |
| 653 | a gene linkage disequilibrium | |
| 653 | a genetic risk | |
| 653 | a genetic variability | |
| 653 | a heritability | |
| 653 | a human | |
| 653 | a Parkinson disease | |
| 653 | a phenotypic variation | |
| 653 | a pleiotropy | |
| 653 | a priority journal | |
| 653 | a single nucleotide polymorphism | |
| 700 | 1 | a Escott-Price, V.4 aut |
| 700 | 1 | a Hernandez, D. G.4 aut |
| 700 | 1 | a Kun-Rodrigues, C.4 aut |
| 700 | 1 | a Ross, O. A.4 aut |
| 700 | 1 | a Orme, T.4 aut |
| 700 | 1 | a Neto, J. L.4 aut |
| 700 | 1 | a Carmona, S.4 aut |
| 700 | 1 | a Dehghani, N.4 aut |
| 700 | 1 | a Eicher, J. D.4 aut |
| 700 | 1 | a Shepherd, C.4 aut |
| 700 | 1 | a Parkkinen, L.4 aut |
| 700 | 1 | a Darwent, L.4 aut |
| 700 | 1 | a Heckman, M. G.4 aut |
| 700 | 1 | a Scholz, S. W.4 aut |
| 700 | 1 | a Troncoso, J. C.4 aut |
| 700 | 1 | a Pletnikova, O.4 aut |
| 700 | 1 | a Dawson, T.4 aut |
| 700 | 1 | a Rosenthal, L.4 aut |
| 700 | 1 | a Ansorge, O.4 aut |
| 700 | 1 | a Clarimon, J.4 aut |
| 700 | 1 | a Lleo, A.4 aut |
| 700 | 1 | a Morenas-Rodriguez, E.4 aut |
| 700 | 1 | a Clark, L.4 aut |
| 700 | 1 | a Honig, L. S.4 aut |
| 700 | 1 | a Marder, K.4 aut |
| 700 | 1 | a Lemstra, A.4 aut |
| 700 | 1 | a Rogaeva, E.4 aut |
| 700 | 1 | a St. George-Hyslop, P.4 aut |
| 700 | 1 | a Londos, Elisabetu Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)pski-elo |
| 700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
| 700 | 1 | a Barber, I.4 aut |
| 700 | 1 | a Braae, A.4 aut |
| 700 | 1 | a Brown, K.4 aut |
| 700 | 1 | a Morgan, K.4 aut |
| 700 | 1 | a Troakes, C.4 aut |
| 700 | 1 | a Al-Sarraj, S.4 aut |
| 700 | 1 | a Lashley, T.4 aut |
| 700 | 1 | a Holton, J.4 aut |
| 700 | 1 | a Compta, Y.4 aut |
| 700 | 1 | a Van Deerlin, V.4 aut |
| 700 | 1 | a Serrano, G. E.4 aut |
| 700 | 1 | a Beach, T. G.4 aut |
| 700 | 1 | a Lesage, S.4 aut |
| 700 | 1 | a Galasko, D.4 aut |
| 700 | 1 | a Masliah, E.4 aut |
| 700 | 1 | a Santana, I.4 aut |
| 700 | 1 | a Pastor, P.4 aut |
| 700 | 1 | a Diez-Fairen, M.4 aut |
| 700 | 1 | a Aguilar, M.4 aut |
| 700 | 1 | a Tienari, P. J.4 aut |
| 700 | 1 | a Myllykangas, L.4 aut |
| 700 | 1 | a Oinas, M.4 aut |
| 700 | 1 | a Revesz, T.4 aut |
| 700 | 1 | a Lees, A.4 aut |
| 700 | 1 | a Boeve, B. F.4 aut |
| 700 | 1 | a Petersen, R. C.4 aut |
| 700 | 1 | a Ferman, T. J.4 aut |
| 700 | 1 | a Graff-Radford, N.4 aut |
| 700 | 1 | a Cairns, N. J.4 aut |
| 700 | 1 | a Morris, J. C.4 aut |
| 700 | 1 | a Pickering-Brown, S.4 aut |
| 700 | 1 | a Mann, D.4 aut |
| 700 | 1 | a Halliday, G. M.4 aut |
| 700 | 1 | a Hardy, J.4 aut |
| 700 | 1 | a Trojanowski, J. Q.4 aut |
| 700 | 1 | a Dickson, D. W.4 aut |
| 700 | 1 | a Singleton, A.4 aut |
| 700 | 1 | a Stone, D. J.4 aut |
| 700 | 1 | a Bras, J.u University College London4 aut |
| 710 | 2 | a University College Londonb Klinisk minnesforskning4 org |
| 773 | 0 | t Neurobiology of Diseased : Elsevier BVg 127, s. 492-501q 127<492-501x 0969-9961 |
| 856 | 4 | u https://helda.helsinki.fi/bitstream/10138/313958/1/Heritability_and_genetic_variance_of_dementia_with_Lewy_bodies.pdf |
| 856 | 4 | u http://dx.doi.org/10.1016/j.nbd.2019.04.004y FULLTEXT |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/281582 |
| 856 | 4 8 | u https://doi.org/10.1016/j.nbd.2019.04.004 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/6f3d41c8-ef68-4340-ad12-8375abfb9791 |
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- Guerreiro, R.
- Escott-Price, V.
- Hernandez, D. G.
- Kun-Rodrigues, C ...
- Ross, O. A.
- Orme, T.
- visa fler...
- Neto, J. L.
- Carmona, S.
- Dehghani, N.
- Eicher, J. D.
- Shepherd, C.
- Parkkinen, L.
- Darwent, L.
- Heckman, M. G.
- Scholz, S. W.
- Troncoso, J. C.
- Pletnikova, O.
- Dawson, T.
- Rosenthal, L.
- Ansorge, O.
- Clarimon, J.
- Lleo, A.
- Morenas-Rodrigue ...
- Clark, L.
- Honig, L. S.
- Marder, K.
- Lemstra, A.
- Rogaeva, E.
- St. George-Hyslo ...
- Londos, Elisabet
- Zetterberg, Henr ...
- Barber, I.
- Braae, A.
- Brown, K.
- Morgan, K.
- Troakes, C.
- Al-Sarraj, S.
- Lashley, T.
- Holton, J.
- Compta, Y.
- Van Deerlin, V.
- Serrano, G. E.
- Beach, T. G.
- Lesage, S.
- Galasko, D.
- Masliah, E.
- Santana, I.
- Pastor, P.
- Diez-Fairen, M.
- Aguilar, M.
- Tienari, P. J.
- Myllykangas, L.
- Oinas, M.
- Revesz, T.
- Lees, A.
- Boeve, B. F.
- Petersen, R. C.
- Ferman, T. J.
- Graff-Radford, N ...
- Cairns, N. J.
- Morris, J. C.
- Pickering-Brown, ...
- Mann, D.
- Halliday, G. M.
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- Trojanowski, J. ...
- Dickson, D. W.
- Singleton, A.
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- Bras, J.
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