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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03611naa a2200397 4500 | |
| 001 | oai:lup.lub.lu.se:14f03688-46eb-4438-b882-4b83f4c3ae02 | |
| 003 | SwePub | |
| 008 | 160401s1996 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11108902 URI |
| 024 | 7 | a https://doi.org/10.1093/ije/25.5.9532 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Råstam, Lennartu Lund University,Lunds universitet,Samhällsmedicin,Forskargrupper vid Lunds universitet,Community Medicine,Lund University Research Groups4 aut0 (Swepub:lu)smi-lra |
| 245 | 1 0 | a Association between serum sialic acid concentration and carotid atherosclerosis measured by B-mode ultrasound. The ARIC Investigators. Atherosclerosis Risk in Communities Study |
| 264 | 1 | b Oxford University Press (OUP),c 1996 |
| 520 | a BACKGROUND: Previous studies have shown that the serum level of sialic acid is associated positively with mortality from coronary disease and stroke. In this study its relation with carotid atherosclerosis was evaluated. METHODS: From the Atherosclerosis Risk in Communities (ARIC) Study, 323 cases with carotid intima-media wall thickness above the 90th percentile (measured with B-mode ultrasound) were matched 1:1 with controls without atherosclerosis. Serum sialic acid, plasma LDL and HDL cholesterol, serum insulin concentrations, blood pressure, antihypertensive medication use, and smoking status were used to assess the independent contribution of the sialic acid level to carotid atherosclerosis. RESULTS: The mean (SD) serum sialic acid concentration was 75.0 (9.7) mg/dl in cases and 70.7 (8.9) mg/dl in controls (P = 0.0001). In a conditional logistic model with adjustment for age, LDL-cholesterol, HDL-cholesterol, serum insulin, smoking and hypertension, the odds ratio associated with sialic acid above the 75th percentile (> or = 78.3 mg/dl) versus below was 1.65 with a 95% confidence interval of 1.01-2.70. CONCLUSION: The sialic acid level is correlated with the presence of carotid atherosclerosis, independently of major cardiovascular disease risk factors. The biological mechanism behind this association is not resolved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
| 653 | a glycoproteins | |
| 653 | a atherosclerosis | |
| 653 | a B-mode ultrasound | |
| 653 | a sialic acid | |
| 700 | 1 | a Lindberg, Gunnar4 aut |
| 700 | 1 | a Folsom, Aaron R4 aut |
| 700 | 1 | a Burke, Gregory L4 aut |
| 700 | 1 | a Nilsson-Ehle, Peteru Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kkem-pne |
| 700 | 1 | a Lundblad, Arne4 aut |
| 710 | 2 | a Samhällsmedicinb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t International Journal of Epidemiologyd : Oxford University Press (OUP)g 25:5, s. 953-958q 25:5<953-958x 1464-3685x 0300-5771 |
| 856 | 4 | u http://dx.doi.org/10.1093/ije/25.5.953x freey FULLTEXT |
| 856 | 4 | u https://academic.oup.com/ije/article-pdf/25/5/953/2021552/25-5-953.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1110890 |
| 856 | 4 8 | u https://doi.org/10.1093/ije/25.5.953 |
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