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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12062naa a2202893 4500 | |
| 001 | oai:lup.lub.lu.se:c4b613ce-c2cd-42d6-a46e-1af4cf77c371 | |
| 003 | SwePub | |
| 008 | 160401s2015 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:131341704 | |
| 024 | 7 | a https://lup.lub.lu.se/record/74107492 URI |
| 024 | 7 | a https://doi.org/10.1093/jnci/djv0362 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1313417042 URI |
| 040 | a (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Mavaddat, Nasim4 aut |
| 245 | 1 0 | a Prediction of Breast Cancer Risk Based on Profiling With Common Genetic Variants |
| 264 | c 2015-04-02 | |
| 264 | 1 | b Oxford University Press (OUP),c 2015 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Background: Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic risk stratification is lacking. Methods: We investigated the value of using 77 breast cancer-associated single nucleotide polymorphisms (SNPs) for risk stratification, in a study of 33 673 breast cancer cases and 33 381 control women of European origin. We tested all possible pair-wise multiplicative interactions and constructed a 77-SNP polygenic risk score (PRS) for breast cancer overall and by estrogen receptor (ER) status. Absolute risks of breast cancer by PRS were derived from relative risk estimates and UK incidence and mortality rates. Results: There was no strong evidence for departure from a multiplicative model for any SNP pair. Women in the highest 1% of the PRS had a three-fold increased risk of developing breast cancer compared with women in the middle quintile (odds ratio [OR] = 3.36, 95% confidence interval [CI] = 2.95 to 3.83). The ORs for ER-positive and ER-negative disease were 3.73 (95% CI = 3.24 to 4.30) and 2.80 (95% CI = 2.26 to 3.46), respectively. Lifetime risk of breast cancer for women in the lowest and highest quintiles of the PRS were 5.2% and 16.6% for a woman without family history, and 8.6% and 24.4% for a woman with a first-degree family history of breast cancer. Conclusions: The PRS stratifies breast cancer risk in women both with and without a family history of breast cancer. The observed level of risk discrimination could inform targeted screening and prevention strategies. Further discrimination may be achievable through combining the PRS with lifestyle/environmental factors, although these were not considered in this report. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 700 | 1 | a Pharoah, Paul D. P.4 aut |
| 700 | 1 | a Michailidou, Kyriaki4 aut |
| 700 | 1 | a Tyrer, Jonathan4 aut |
| 700 | 1 | a Brook, Mark N.4 aut |
| 700 | 1 | a Bolla, Manjeet K.4 aut |
| 700 | 1 | a Wang, Qin4 aut |
| 700 | 1 | a Dennis, Joe4 aut |
| 700 | 1 | a Dunning, Alison M.4 aut |
| 700 | 1 | a Shah, Mitul4 aut |
| 700 | 1 | a Luben, Robert4 aut |
| 700 | 1 | a Brown, Judith4 aut |
| 700 | 1 | a Bojesen, Stig E.4 aut |
| 700 | 1 | a Nordestgaard, Borge G.4 aut |
| 700 | 1 | a Nielsen, Sune F.4 aut |
| 700 | 1 | a Flyger, Henrik4 aut |
| 700 | 1 | a Czene, Kamilau Karolinska Institutet4 aut |
| 700 | 1 | a Darabi, Hatef4 aut |
| 700 | 1 | a Eriksson, Mikaelu Karolinska Institutet4 aut |
| 700 | 1 | a Peto, Julian4 aut |
| 700 | 1 | a dos-Santos-Silva, Isabel4 aut |
| 700 | 1 | a Dudbridge, Frank4 aut |
| 700 | 1 | a Johnson, Nichola4 aut |
| 700 | 1 | a Schmidt, Marjanka K.4 aut |
| 700 | 1 | a Broeks, Annegien4 aut |
| 700 | 1 | a Verhoef, Senno4 aut |
| 700 | 1 | a Rutgers, Emiel J.4 aut |
| 700 | 1 | a Swerdlow, Anthony4 aut |
| 700 | 1 | a Ashworth, Alanu Karolinska Institutet4 aut |
| 700 | 1 | a Orr, Nick4 aut |
| 700 | 1 | a Schoemaker, Minouk J.4 aut |
| 700 | 1 | a Figueroa, Jonine4 aut |
| 700 | 1 | a Chanock, Stephen J.4 aut |
| 700 | 1 | a Brinton, Louise4 aut |
| 700 | 1 | a Lissowska, Jolanta4 aut |
| 700 | 1 | a Couch, Fergus J.4 aut |
| 700 | 1 | a Olson, Janet E.4 aut |
| 700 | 1 | a Vachon, Celine4 aut |
| 700 | 1 | a Pankratz, Vernon S.4 aut |
| 700 | 1 | a Lambrechts, Diether4 aut |
| 700 | 1 | a Wildiers, Hans4 aut |
| 700 | 1 | a Van Ongeval, Chantal4 aut |
| 700 | 1 | a Van Limbergen, Erik4 aut |
| 700 | 1 | a Kristensen, Vessela4 aut |
| 700 | 1 | a Alnaes, Grethe Grenaker4 aut |
| 700 | 1 | a Nord, Silje4 aut |
| 700 | 1 | a Borresen-Dale, Anne-Lise4 aut |
| 700 | 1 | a Nevanlinna, Heli4 aut |
| 700 | 1 | a Muranen, Taru A.4 aut |
| 700 | 1 | a Aittomaeki, Kristiina4 aut |
| 700 | 1 | a Blomqvist, Carl4 aut |
| 700 | 1 | a Chang-Claude, Jenny4 aut |
| 700 | 1 | a Rudolph, Anja4 aut |
| 700 | 1 | a Seibold, Petra4 aut |
| 700 | 1 | a Flesch-Janys, Dieter4 aut |
| 700 | 1 | a Fasching, Peter A.4 aut |
| 700 | 1 | a Haeberle, Lothar4 aut |
| 700 | 1 | a Ekici, Arif B.4 aut |
| 700 | 1 | a Beckmann, Matthias W.4 aut |
| 700 | 1 | a Burwinkel, Barbara4 aut |
| 700 | 1 | a Marme, Frederik4 aut |
| 700 | 1 | a Schneeweiss, Andreas4 aut |
| 700 | 1 | a Sohn, Christof4 aut |
| 700 | 1 | a Trentham-Dietz, Amy4 aut |
| 700 | 1 | a Newcomb, Polly4 aut |
| 700 | 1 | a Titus, Linda4 aut |
| 700 | 1 | a Egan, Kathleen M.4 aut |
| 700 | 1 | a Hunter, David J.4 aut |
| 700 | 1 | a Lindstrom, Sara4 aut |
| 700 | 1 | a Tamimi, Rulla M.4 aut |
| 700 | 1 | a Kraft, Peter4 aut |
| 700 | 1 | a Rahman, Nazneen4 aut |
| 700 | 1 | a Turnbull, Clare4 aut |
| 700 | 1 | a Renwick, Anthony4 aut |
| 700 | 1 | a Seal, Sheilau Karolinska Institutet4 aut |
| 700 | 1 | a Li, Jingmei4 aut |
| 700 | 1 | a Liu, Jianjun4 aut |
| 700 | 1 | a Humphreys, Keithu Karolinska Institutet4 aut |
| 700 | 1 | a Benitez, Javier4 aut |
| 700 | 1 | a Zamora, M. Pilar4 aut |
| 700 | 1 | a Perez, Jose Ignacio Arias4 aut |
| 700 | 1 | a Menendez, Primitiva4 aut |
| 700 | 1 | a Jakubowska, Anna4 aut |
| 700 | 1 | a Lubinski, Jan4 aut |
| 700 | 1 | a Jaworska-Bieniek, Katarzyna4 aut |
| 700 | 1 | a Durda, Katarzyna4 aut |
| 700 | 1 | a Bogdanova, Natalia V.4 aut |
| 700 | 1 | a Antonenkova, Natalia N.4 aut |
| 700 | 1 | a Doerk, Thilo4 aut |
| 700 | 1 | a Anton-Culver, Hoda4 aut |
| 700 | 1 | a Neuhausen, Susan L.4 aut |
| 700 | 1 | a Ziogas, Argyrios4 aut |
| 700 | 1 | a Bernstein, Leslie4 aut |
| 700 | 1 | a Devilee, Peter4 aut |
| 700 | 1 | a Tollenaar, Robert A. E. M.4 aut |
| 700 | 1 | a Seynaeve, Caroline4 aut |
| 700 | 1 | a van Asperen, Christi J.4 aut |
| 700 | 1 | a Cox, Angela4 aut |
| 700 | 1 | a Cross, Simon S.4 aut |
| 700 | 1 | a Reed, Malcolm W. R.4 aut |
| 700 | 1 | a Khusnutdinova, Elza4 aut |
| 700 | 1 | a Bermisheva, Marina4 aut |
| 700 | 1 | a Prokofyeva, Darya4 aut |
| 700 | 1 | a Takhirova, Zalina4 aut |
| 700 | 1 | a Meindl, Alfons4 aut |
| 700 | 1 | a Schmutzler, Rita K.4 aut |
| 700 | 1 | a Sutter, Christian4 aut |
| 700 | 1 | a Yang, Rongxi4 aut |
| 700 | 1 | a Schuermann, Peter4 aut |
| 700 | 1 | a Bremer, Michael4 aut |
| 700 | 1 | a Christiansen, Hans4 aut |
| 700 | 1 | a Park-Simon, Tjoung-Won4 aut |
| 700 | 1 | a Hillemanns, Peter4 aut |
| 700 | 1 | a Guenel, Pascal4 aut |
| 700 | 1 | a Truong, Therese4 aut |
| 700 | 1 | a Menegaux, Florence4 aut |
| 700 | 1 | a Sanchez, Marie4 aut |
| 700 | 1 | a Radice, Paolo4 aut |
| 700 | 1 | a Peterlongo, Paolou Karolinska Institutet4 aut |
| 700 | 1 | a Manoukian, Siranoush4 aut |
| 700 | 1 | a Pensotti, Valeria4 aut |
| 700 | 1 | a Hopper, John L.4 aut |
| 700 | 1 | a Tsimiklis, Helen4 aut |
| 700 | 1 | a Apicella, Carmel4 aut |
| 700 | 1 | a Southey, Melissa C.4 aut |
| 700 | 1 | a Brauch, Hiltrud4 aut |
| 700 | 1 | a Bruening, Thomas4 aut |
| 700 | 1 | a Ko, Yon-Dschun4 aut |
| 700 | 1 | a Sigurdson, Alice J.4 aut |
| 700 | 1 | a Doody, Michele M.4 aut |
| 700 | 1 | a Hamann, Ute4 aut |
| 700 | 1 | a Torres, Diana4 aut |
| 700 | 1 | a Ulmer, Hans-Ulrich4 aut |
| 700 | 1 | a Försti, Astau Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-asf |
| 700 | 1 | a Sawyer, Elinor J.4 aut |
| 700 | 1 | a Tomlinson, Ian4 aut |
| 700 | 1 | a Kerin, Michael J.4 aut |
| 700 | 1 | a Miller, Nicola4 aut |
| 700 | 1 | a Andrulis, Irene L.4 aut |
| 700 | 1 | a Knight, Julia A.4 aut |
| 700 | 1 | a Glendon, Gord4 aut |
| 700 | 1 | a Mulligan, Anna Marie4 aut |
| 700 | 1 | a Chenevix-Trench, Georgia4 aut |
| 700 | 1 | a Balleine, Rosemary4 aut |
| 700 | 1 | a Giles, Graham G.4 aut |
| 700 | 1 | a Milne, Roger L.4 aut |
| 700 | 1 | a McLean, Catriona4 aut |
| 700 | 1 | a Lindblom, Annika4 aut |
| 700 | 1 | a Margolin, Sara4 aut |
| 700 | 1 | a Haiman, Christopher A.4 aut |
| 700 | 1 | a Henderson, Brian E.4 aut |
| 700 | 1 | a Schumacher, Fredrick4 aut |
| 700 | 1 | a Le Marchand, Loic4 aut |
| 700 | 1 | a Eilber, Ursula4 aut |
| 700 | 1 | a Wang-Gohrke, Shan4 aut |
| 700 | 1 | a Hooning, Maartje J.4 aut |
| 700 | 1 | a Hollestelle, Antoinette4 aut |
| 700 | 1 | a van den Ouweland, Ans M. W.4 aut |
| 700 | 1 | a Koppert, Linetta B.4 aut |
| 700 | 1 | a Carpenter, Jane4 aut |
| 700 | 1 | a Clarke, Christine4 aut |
| 700 | 1 | a Scott, Rodney4 aut |
| 700 | 1 | a Mannermaa, Arto4 aut |
| 700 | 1 | a Kataja, Vesa4 aut |
| 700 | 1 | a Kosma, Veli-Matti4 aut |
| 700 | 1 | a Hartikainen, Jaana M.4 aut |
| 700 | 1 | a Brenner, Hermann4 aut |
| 700 | 1 | a Arndt, Volker4 aut |
| 700 | 1 | a Stegmaier, Christa4 aut |
| 700 | 1 | a Dieffenbach, Aida Karina4 aut |
| 700 | 1 | a Winqvist, Robert4 aut |
| 700 | 1 | a Pylkaes, Katri4 aut |
| 700 | 1 | a Jukkola-Vuorinen, Arja4 aut |
| 700 | 1 | a Grip, Mervi4 aut |
| 700 | 1 | a Offit, Kenneth4 aut |
| 700 | 1 | a Vijai, Joseph4 aut |
| 700 | 1 | a Robson, Mark4 aut |
| 700 | 1 | a Rau-Murthy, Rohini4 aut |
| 700 | 1 | a Dwek, Miriam4 aut |
| 700 | 1 | a Swann, Ruth4 aut |
| 700 | 1 | a Perkins, Katherine Annie4 aut |
| 700 | 1 | a Goldberg, Mark S.4 aut |
| 700 | 1 | a Labreche, France4 aut |
| 700 | 1 | a Dumont, Martine4 aut |
| 700 | 1 | a Eccles, Diana M.4 aut |
| 700 | 1 | a Tapper, William J.4 aut |
| 700 | 1 | a Rafiq, Sajjad4 aut |
| 700 | 1 | a John, Esther M.4 aut |
| 700 | 1 | a Whittemore, Alice S.4 aut |
| 700 | 1 | a Slager, Susan4 aut |
| 700 | 1 | a Yannoukakos, Drakoulis4 aut |
| 700 | 1 | a Toland, Amanda E.4 aut |
| 700 | 1 | a Yao, Song4 aut |
| 700 | 1 | a Zheng, Wei4 aut |
| 700 | 1 | a Halverson, Sandra L.4 aut |
| 700 | 1 | a Gonzalez-Neira, Anna4 aut |
| 700 | 1 | a Pita, Guillermo4 aut |
| 700 | 1 | a Alonso, M. Rosario4 aut |
| 700 | 1 | a Alvarez, Nuria4 aut |
| 700 | 1 | a Herrero, Daniel4 aut |
| 700 | 1 | a Tessier, Daniel C.4 aut |
| 700 | 1 | a Vincent, Daniel4 aut |
| 700 | 1 | a Bacot, Francois4 aut |
| 700 | 1 | a Luccarini, Craig4 aut |
| 700 | 1 | a Baynes, Caroline4 aut |
| 700 | 1 | a Ahmed, Shahana4 aut |
| 700 | 1 | a Maranian, Mel4 aut |
| 700 | 1 | a Healey, Catherine S.4 aut |
| 700 | 1 | a Simard, Jacques4 aut |
| 700 | 1 | a Hall, Per4 aut |
| 700 | 1 | a Easton, Douglas F.4 aut |
| 700 | 1 | a Garcia-Closas, Montserrat4 aut |
| 710 | 2 | a Karolinska Institutetb Allmänmedicin och klinisk epidemiologi4 org |
| 773 | 0 | t Journal of the National Cancer Instituted : Oxford University Press (OUP)g 107:5, s. 036-036q 107:5<036-036x 1460-2105x 0027-8874 |
| 856 | 4 | u https://portal.research.lu.se/files/3347292/8523669.pdfx primaryx freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1093/jnci/djv036x freey FULLTEXT |
| 856 | 4 | u https://academic.oup.com/jnci/article-pdf/107/5/djv036/17314544/djv036.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/7410749 |
| 856 | 4 8 | u https://doi.org/10.1093/jnci/djv036 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:131341704 |
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