High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma

Tyck till om SwePub Sök här!

Amini, Rose-Marie (author): Uppsala universitet,Molekylär och morfologisk patologi

(creator_code:org_t)

2012-12-10
2013
English.
In: Oncology Reports. - : Spandidos Publications. - 1021-335X .- 1791-2431. ; 29:2, s. 720-724

Related links:: https://www.spandido...; show more...; https://urn.kb.se/re...; https://doi.org/10.3...; show less...

Abstract Subject headings

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. A new and important tool for understanding the biology and clinical course of DLBCL is microRNA expression. This study presents microRNA-200c expression data from 61 DLBCL patients treated with CHOP or R-CHOP. Patients with high microRNA-200c expression had a median survival of 20.3 months and a significantly shorter overall survival (P=0.019) compared to patients with low microRNA-200c expression, who had a median survival of 35.8 months. We also found that patients treated with R-CHOP only and displaying high microRNA-200c expression had a significantly shorter overall survival compared to patients with low microRNA-200c expression, where all patients were still alive at the time of the last follow-up (P=0.0036). Lastly, we found that patients with high microRNA-200c expression had a significantly shorter time from initial diagnosis to the first relapse compared to patients with low microRNA-200c expression (P=0.0001). To our knowledge, this is the first study showing that the expression of microRNA-200c affects the clinical outcome of DLBCL patients, and that microRNA-200c is involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-200c in DLBCL.

By the author/editor: Berglund, Mattia ...; Hedström, Gustaf; Amini, Rose-Mari ...; Enblad, Gunilla; Thunberg, Ulf

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.