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Sökning: WFRF:(Nakagawa Hidewaki) > Implementation of W...

Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care

Cuppen, Edwin (författare)
Hartwig Medical Foundation, Amsterdam, the Netherlands;Center for Molecular Medicine and Oncode Institute, University Medical Center, Utrecht, the Netherlands
Elemento, Olivier (författare)
Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA
Rosenquist, Richard (författare)
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden;Clinical Genetics, Karolinska University Hospital, Solna, Sweden
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Nikic, Svetlana (författare)
Illumina Productos de España, S.L.U., Plaza Pablo Ruiz Picasso, Madrid, Spain
IJzerman, Maarten (författare)
Erasmus School of Health Policy & Management, Erasmus University, Rotterdam, the Netherlands;Centre for Cancer Research, University of Melbourne, Melbourne, Australia
Zaleski, Isabelle Durand (författare)
Université de Paris, CRESS, INSERM, INRA, URCEco, AP-HP, Hôpital de l'Hôtel Dieu, Paris, France
Frederix, Geert (författare)
Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, the Netherlands
Levin, Lars-Åke, Professor, 1960- (författare)
Linköpings universitet,Avdelningen för samhälle och hälsa,Medicinska fakulteten
Mullighan, Charles G. (författare)
Department of Pathology, St Jude Children's Research Hospital, Memphis, TN, USA
Buettner, Reinhard (författare)
Institute of Pathology, University Hospital Cologne, Germany
Pugh, Trevor J. (författare)
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada;Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada;Ontario Institute for Cancer Research, Toronto, Ontario, Canada
Grimmond, Sean (författare)
Centre for Cancer Research, University of Melbourne, Melbourne, Australia
Caldas, Carlos (författare)
Cancer Research UK Cambridge Institute and Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Andre, Fabrice (författare)
Institut Gustave Roussy, Villejuif, France
Custers, Ilse (författare)
Stichting Lygature, Utrecht, the Netherlands
Campo, Elias (författare)
Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain;Centro de Investigación Biomédica en Red, Cáncer (CIBERONC), Madrid, Spain;Hematopathology Unit, Hospital Clínic of Barcelona, Barcelona, Spain;University of Barcelona, Barcelona, Spain
van Snellenberg, Hans (författare)
Hartwig Medical Foundation, Amsterdam, the Netherlands
Schuh, Anna (författare)
University of Oxford, Oxford, United Kingdom
Nakagawa, Hidewaki (författare)
Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan
von Kalle, Christof (författare)
Berlin Institute of Health at Charité—Universitätsmedizin Berlin, Clinical Study Center, Berlin, Germany
Haferlach, Torsten (författare)
Munich Leukemia Laboratory, Munich, Germany
Fröhling, Stefan (författare)
Division of Translational Medical Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany;German Cancer Consortium (DKTK), Heidelberg, Germany
Jobanputra, Vaidehi (författare)
New York Genome Center; Department of Pathology, Columbia University Irving Medical Center, New York, NY
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 (creator_code:org_t)
American Society of Clinical Oncology, 2022
2022
Engelska.
Ingår i: JCO Precision Oncology. - : American Society of Clinical Oncology. - 2473-4284. ; 6
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • PURPOSE The combination of whole-genome and transcriptome sequencing (WGTS) is expected to transformdiagnosis and treatment for patients with cancer. WGTS is a comprehensive precision diagnostic test that isstarting to replace the standard of care for oncology molecular testing in health care systems around the world;however, the implementation and widescale adoption of this best-in-class testing is lacking.METHODS Here, we address the barriers in integrating WGTS for cancer diagnostics and treatment selection andanswer questions regarding utility in different cancer types, cost-effectiveness and affordability, and otherpractical considerations for WGTS implementation.RESULTS We review the current studies implementing WGTS in health care systems and provide a synopsis of theclinical evidence and insights into practical considerations for WGTS implementation. We reflect on regulatory,costs, reimbursement, and incidental findings aspects of this test.CONCLUSION WGTS is an appropriate comprehensive clinical test for many tumor types and can replacemultiple, cascade testing approaches currently performed. Decreasing sequencing cost, increasing number ofclinically relevant aberrations and discovery of more complex biomarkers of treatment response, should pave theway for health care systems and laboratories in implementing WGTS into clinical practice, to transform diagnosisand treatment for patients with cancer.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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