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Sökning: WFRF:(Malmström Vivianne) > Atherosclerosis in ...

Atherosclerosis in rheumatoid arthritis : associations between anti-cytomegalovirus IgG antibodies, CD4+CD28null T-cells, CD8+CD28null T-cells and intima-media thickness

Wahlin, Bengt (författare)
Umeå universitet,Reumatologi
Fasth, Andreas (författare)
Karp, Kjell (författare)
Umeå universitet,Klinisk fysiologi
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Lejon, Kristina, 1967- (författare)
Umeå universitet,Immunologi/immunkemi
Malmström, Vivianne (författare)
Karolinska Institutet
Rahbar, Afsar (författare)
Karolinska Institutet
Wållberg-Jonsson, Solveig, 1953- (författare)
Umeå universitet,Reumatologi
Södergren, Anna, 1977- (författare)
Umeå universitet,Reumatologi,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
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 (creator_code:org_t)
Clinical and Experimental Rheumatology S.A.S. 2021
2021
Engelska.
Ingår i: Clinical and Experimental Rheumatology. - : Clinical and Experimental Rheumatology S.A.S.. - 0392-856X .- 1593-098X. ; 39:3, s. 578-586
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.5...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objectives: Patients with rheumatoid arthritis (RA) have an accelerated progression of atherosclerosis. The aims of this study were to study the associations between subsets of T-cells, subclinical atherosclerosis assessed by intima-media thickness (IMT) and serological status for CMV in patients with RA.Methods: Patients with new-onset RA (n=79), aged ≤60 years at diagnosis, were included in a prospective study of atherosclerosis. Controls matched for age and sex were also included (n=44). Ultrasound measurement of IMT in the common carotid artery was undertaken at inclusion (T0), after 1.5 years (T1.5) and after 11 years (T11). At T11, flow-cytometry analysis was undertaken to investigate subsets of T-cells. Serological analysis for CMV was undertaken from samples collected at T0.Results: At T0, 66% of the patients and controls were CMV immunoglobulin G-positive. CMV-IgG positive patients had a significantly more rapid increase in IMT at T1.5, compared with controls and CMV-IgG negative patients. CMV-IgG positive patients had a significantly higher percentage of T-cells lacking CD28 (both CD4+CD28null and CD8+CD28null T-cells) than CMV-IgG negative patients. Increased levels of CD4+CD28null and CD8+CD28null T-cells were significantly associated with IMT at T11, adjusted for systolic blood pressure. CX3CR1 was expressed in CD4+ and CD8+ CD28null T-cells, but CX3CR1 per se was not associated with increased IMT.Conclusions: Presence of CMV IgG-antibodies in patients with RA is associated with altered T-cell-populations and an increased burden of atherosclerosis. A possible protective effect of antiviral treatment in CMV-positive patients with new-onset RA should be considered.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Nyckelord

rheumatoid arthritis
atherosclerosis
T-cells
CD28
cytomegalovirus

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