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H3 K27M-Altered Dif...
H3 K27M-Altered Diffuse Midline Gliomas : A Review
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- Wisniewski, Karol (författare)
- Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Australia.;Med Univ Lodz, Dept Neurosurg & Neurooncol, Lodz, Poland
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- Ghaly, Andrew (författare)
- Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Australia
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- Drummond, Kate (författare)
- Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Australia.;Univ Melbourne, Royal Melbourne Hosp, Dept Surg, Melbourne, Australia.;Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Vic 3051, Australia
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- Fahlström, Andreas (författare)
- Uppsala universitet,Neurokirurgi,Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Australia
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Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Australia;Med Univ Lodz, Dept Neurosurg & Neurooncol, Lodz, Poland Royal Melbourne Hosp, Dept Neurosurg, Melbourne, Australia (creator_code:org_t)
- Georg Thieme Verlag KG, 2023
- 2023
- Engelska.
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Ingår i: Indian Journal of Neurosurgery. - : Georg Thieme Verlag KG. - 2277-954X .- 2277-9167. ; 12:02, s. 104-115
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Diffuse midline glioma H3 K27M-altered is a recently renamed high-grade glioma in the 2021 World Health Organization (WHO) Classification of Central Nervous System Tumors, previously being labelled diffuse midline glioma H3 K27M-mutant in the 2016 update and diffuse intrinsic pontine glioma prior to 2016. After identification of multiple alterations causing H3 K27 hypomethylation, the definition of this tumor subtype was changed. To further characterize this new entity in both the pediatric and adult population, we conducted a review of the current literature, investigating genetic, epidemiological, clinical, radiological, histopathological, treatment and prognostic characteristics, particularly highlighting the differences between adults and children. This tumor is more common in children, and has a poorer prognosis. Additionally, childhood H3 K27-altered gliomas are more common in the brainstem, but more common in the thalamus in adults. Sadly, limited treatment options exist for these tumors, with radiotherapy the only treatment shown to improve overall survival.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- diffuse midline glioma
- 1 or H3
- 2 K27-mutant
- H3-wildtype with EZHIP overexpression
- EGFR -mutant
- 3 K27-mutant
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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