Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies

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To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and lung cancer risk. We conducted a case-control study nested within 3 prospective cohort studies-the Melbourne Collaborative Cohort Study (1990-1994), the Malm Diet and Cancer Study (1991-1996), and the Northern Sweden Health and Disease Study (initiated in 1985)-involving 807 incident lung cancer cases and 807 smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations were used to estimate odds ratios for lung cancer risk associated with concentrations of interleukin (IL)-1 beta, IL-2, IL-6, IL-8, IL-10, IL-12, interferon., tumor necrosis factor a, and granulocyte-macrophage colony-stimulating factor. We observed a higher lung cancer risk for participants with elevated concentrations of IL-6 and IL-8. These associations seemed to be stronger among former smokers (for fourth quartile vs. first quartile, odds ratio (OR) = 2.70, 95% confidence interval (CI): 1.55, 4.70) and current smokers (OR = 1.99, 95% CI: 1.15, 3.44) for IL-6 and among former smokers (OR = 2.83, 95% CI: 1.18, 6.75) and current smokers (OR = 1.30, 95% CI: 0.69, 2.44) for IL-8. No notable associations were observed among never smokers. Risk associations with IL-6 and IL-8 were observed for blood samples taken close to diagnosis (< 5 years) as well as more than 15 years postdiagnosis.

Fanidi, Anouar (författare)
Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (författare)
Muller, David C. (författare)
Brennan, Paul (författare)
Manjer, Jonas (författare)
Byrnes, Graham (författare)
Hodge, Allison (författare)
Severi, Gianluca (författare)
Giles, Graham G. (författare)
Johansson, MikaelUmeå universitet,Institutionen för strålningsvetenskaper(Swepub:umu)mijo0025 (författare)
Johansson, Mattias (författare)
Umeå universitetKlinisk kemi (creator_code:org_t)

Ingår i:American Journal of Epidemiology: OXFORD UNIV PRESS INC185:2, s. 86-950002-92621476-6256

Av författaren/redakt...: Brenner, Darren ...; Fanidi, Anouar; Grankvist, Kjell; Muller, David C.; Brennan, Paul; Manjer, Jonas; visa fler...; Byrnes, Graham; Hodge, Allison; Severi, Gianluca; Giles, Graham G.; Johansson, Mikae ...; Johansson, Matti ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Cancer och onkol ...

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