Tyck till om SwePub Sök
här!
Sökning: swepub
> Tidskriftsartikel
> Lunds universitet >
Effectiveness of fi...
Effectiveness of first generation disease-modifying therapy to prevent conversion to secondary progressive multiple sclerosis.
-
- Tedeholm, Helen, 1978 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
-
- Piehl, F (författare)
- Neuroimmunology Unit., Department of Clinical Neuroscience, Karolinska Institute, CMM L8:4 Karolinska University Hospital Solna, Stockholm, Sweden,Unit of Neurology, Östersund Hospital, Östersund, Jämtland Härjedalen Region, Sweden,Karolinska Inst, Karolinska Univ Hosp Solna, Dept Clin Neurosci, Neuroimmunol Unit,CMM L8 4, Stockholm, Sweden.,Östersund Hosp, Unit Neurol, Östersund, Jamtland Harjed, Sweden.
-
- Lycke, Jan, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
-
visa fler...
-
- Link, J. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Stawiarz, L. (författare)
- Karolinska Institutet,Karolinska Inst, Sweden
-
- Burman, Joachim, 1974- (författare)
- Uppsala University,Uppsala universitet,Neurologi,Uppsala Univ, Sweden
-
- de Flon, P. (författare)
- Unit of Neurology, Östersund Hospital, Östersund, Jämtland Härjedalen Region, Sweden
-
- Fink, K. (författare)
- Karolinska Institutet
-
- Gunnarsson, Martin, 1973- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Neurology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Neurol, Örebro, Sweden.
-
- Mellergård, Johan (författare)
- Linköpings universitet,Linköping University,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Neurologiska kliniken i Linköping
-
- Nilsson, P. (författare)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Sweden
-
- Sundström, Peter (författare)
- Umeå University,Umeå universitet,Neurovetenskaper,Karolinska Inst, Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
-
- Svenningsson, A. (författare)
- Karolinska Institutet
-
- Johansson, Helena, 1981 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
-
- Andersen, Oluf, 1941 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience
-
visa färre...
-
(creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
-
Ingår i: Multiple Sclerosis and Related Disorders. - : Elsevier. - 2211-0348 .- 2211-0356. ; 68
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://uu.diva-port... (primary) (Raw object)
-
http://dx.doi.org/10... (free)
-
https://liu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
https://lup.lub.lu.s...
-
https://urn.kb.se/re...
-
http://kipublication...
-
https://gup.ub.gu.se...
-
visa färre...
Abstract
Ämnesord
Stäng
- BACKGROUND: The use of disease-modifying therapies (DMTs) in multiple sclerosis (MS) has been associated with reduced relapse rates and accumulation of disability. However, studies examining impact of DMT on risk of transition to secondary progressive MS (SPMS) leveraging population-based nationwide data are still rare. Here, we determine the population incidence of conversion to SPMS using two consecutive nation-wide cohorts, one immediately before and one after the introduction of DMT in Sweden.METHODS: We included two consecutive population cohorts of relapsing-remitting MS (RRMS) from the Swedish national MS register for the periods 1975-1994 (n = 2161), before DMT availability, and 1995-2011 (n = 3510), in which DMTs, mainly first generation DMT (injectables), became available and eventually were used by 70% of patients. We explored the risk of transition to SPMS as a calendar year function encompassing the two cohorts. In addition, we determined the incidence of transition to SPMS through age strata below and above 50 years in untreated and treated patient subgroups.RESULTS: The risk of conversion to SPMS (adjusted for current age, current time since onset, calendar year and sex) was significantly lower in the second compared with the first population cohort (hazard ratio 0.58; CI 0.48, 0.70). The risk of SPMS conversion per calendar year decreased by 2.6% annually (p < 0.001) after 1995. The risk of SPMS conversion increased with age until age 50. Thereafter, it was unchanged or decreased among those with early MS onset age (<35 years), but continued to increase with onset at higher age, with similar trends in treated and untreated subgroups.CONCLUSION: The incidence of SPMS conversion significantly decreased at the population level after introduction of first generation DMTs by 1995. DMT efficiency was confirmed by a downward turn of the annual trajectory of the risk of SPMS conversion after 1995. An onset age determined pattern of variable SPMS incidence in higher age appeared in both treated and untreated strata. While first generation DMT delayed conversion to SPMS, their long-term effect was only moderate.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Annual incidence
- Disease-modifying therapy
- Multiple sclerosis
- Observational study
- Secondary progression
- Annual incidence
- Disease-modifying therapy
- Multiple sclerosis
- Observational study
- Secondary progression
- Secondary Progression
- Annual Incidence
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Tedeholm, Helen, ...
-
Piehl, F
-
Lycke, Jan, 1956
-
Link, J.
-
Stawiarz, L.
-
Burman, Joachim, ...
-
visa fler...
-
de Flon, P.
-
Fink, K.
-
Gunnarsson, Mart ...
-
Mellergård, Joha ...
-
Nilsson, P.
-
Sundström, Peter
-
Svenningsson, A.
-
Johansson, Helen ...
-
Andersen, Oluf, ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Hälsovetenskap
-
och Folkhälsovetensk ...
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Neurologi
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Immunologi
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
- Artiklar i publikationen
-
Multiple Scleros ...
- Av lärosätet
-
Örebro universitet
-
Umeå universitet
-
Uppsala universitet
-
Lunds universitet
-
Linköpings universitet
-
Karolinska Institutet
-
visa fler...
-
Göteborgs universitet
-
visa färre...