Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET

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Kudomi, NobuyukiTurku PET Centre, University of Turku, Turku, Finland & Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, Japan (author)

Myocardial Blood Flow and Metabolic Rate of Oxygen Measurement in the Right and Left Ventricles at Rest and During Exercise Using 15O-Labeled Compounds and PET

Article/chapterEnglish2019

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2019-06-19
Lausanne :Frontiers Media S.A.2019
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LIBRIS-ID:oai:DiVA.org:hh-41454
https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-41454URI
https://doi.org/10.3389/fphys.2019.00741DOI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Other funders: University of Turku, Turku University Hospital, Åbo Academy, Sigrid Juselius Foundation, JSPS KAKENHI (C) Grant Number 26460728 2014–2016 (NK), The Finnish Cardiovascular Foundation, and The Finnish Diabetes Research Foundation.
Aims: Simultaneous measurement of right (RV) and left ventricle (LV) myocardial blood flow (MBF), oxygen extraction fraction (OEF), and oxygen consumption (MVO2) non-invasively in humans would provide new possibilities to understand cardiac physiology and different patho-physiological states. Methods: We developed and tested an optimized novel method to measure MBF, OEF, and MVO2 simultaneously both in the RV and LV free wall (FW) using positron emission tomography in healthy young men at rest and during supine bicycle exercise. Results: Resting MBF was not significantly different between the three myocardial regions. Exercise increased MBF in the LVFW and septum, but MBF was lower in the RV compared to septum and LVFW during exercise. Resting OEF was similar between the three different myocardial regions (similar to 70%) and increased in response to exercise similarly in all regions. MVO2 increased approximately two to three times from rest to exercise in all myocardial regions, but was significantly lower in the RV during exercise as compared to septum LVFW. Conclusion: MBF, OEF, and MVO2 can be assessed simultaneously in the RV and LV myocardia at rest and during exercise. Although there are no major differences in the MBF and OEF between LV and RV myocardial regions in the resting myocardium, MVO2 per gram of myocardium appears to be lower the RV in the exercising healthy human heart due to lower mean blood flow. The presented method may provide valuable insights for the assessment of MBF, OEF and MVO2 in hearts in different pathophysiological states.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Fysiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Physiology hsv//eng
positron emission tomography
myocardial blood flow
myocardial oxygen metabolism
right ventricle
left ventricle

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Kalliokoski, Kari K.Turku PET Centre, University of Turku, Turku, Finland (author)
Oikonen, Vesa J.Turku PET Centre, University of Turku, Turku, Finland (author)
Han, ChunleiTurku PET Centre, University of Turku, Turku, Finland (author)
Kemppainen, JukkaTurku PET Centre, University of Turku, Turku, Finland & Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland (author)
Sipila, Hannu T.Turku PET Centre, University of Turku, Turku, Finland (author)
Knuuti, JuhaniTurku PET Centre, University of Turku, Turku, Finland & Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland (author)
Heinonen, Ilkka,1982-Högskolan i Halmstad,Rydberglaboratoriet för tillämpad naturvetenskap (RLAS),Turku PET Centre, University of Turku, Turku, Finland & Department of Clinical Physiology and Nuclear Medicine, University of Turku and Turku University Hospital, Turku, Finland(Swepub:hh)ilkhei (author)
Turku PET Centre, University of Turku, Turku, Finland & Department of Medical Physics, Faculty of Medicine, Kagawa University, Kagawa, JapanTurku PET Centre, University of Turku, Turku, Finland (creator_code:org_t)

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In:Frontiers in PhysiologyLausanne : Frontiers Media S.A.101664-042X

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By the author/editor: Kudomi, Nobuyuki; Kalliokoski, Kar ...; Oikonen, Vesa J.; Han, Chunlei; Kemppainen, Jukk ...; Sipila, Hannu T.; show more...; Knuuti, Juhani; Heinonen, Ilkka, ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Physiology

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