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Sökning: onr:"swepub:oai:DiVA.org:kth-19235" > Unilateral Extrapul...

  • Moore, Alastair J.Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)

Unilateral Extrapulmonary Airway Bypass in Advanced Emphysema

  • Artikel/kapitelEngelska2010

Förlag, utgivningsår, omfång ...

  • Elsevier BV,2010
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-19235
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-19235URI
  • https://doi.org/10.1016/j.athoracsur.2009.10.067DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:shh:diva-158URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:120046202URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-488URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • QC 20110210
  • Background. Gas trapping in emphysema results in resting and dynamic hyperinflation. We tested the hypothesis that a direct connection between the lung parenchyma and the atmosphere could increase expiratory flow and thereby potentially improve dyspnea through the relief of gas trapping. Methods. Ex vivo we studied 7 emphysematous lungs and 3 fibrotic lungs (as controls) and measured expiratory flow before and after airway bypass insertion during a forced maneuver in an artificial thorax. Pilot studies were conducted in vivo in 6 patients with advanced emphysema using a size 9 endotracheal tube as a bypass surgically placed through the chest wall into the upper lobe. Results. In the ex vivo emphysematous lungs the volume expelled during a forced expiratory maneuver increased from 169 to 235 mL (p < 0.05). In the in vivo group 4 patients retained the bypass tube for 3 months or more; total lung capacity was reduced, and the forced expiratory volume in 1 second increased by 23% (mean percent predicted at baseline versus 3 months, 24.4% versus 29.5%). Conclusions. An extrapulmonary airway bypass increases expiratory flow in emphysema. This may be a useful approach in hyperinflated patients with homogeneous emphysema. (Ann Thorac Surg 2010;89:899-906)

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Cetti, EdwardDepartment of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)
  • Haj-Yahia, SaleemDepartment of Thoracic Surgery, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)
  • Carby, MartinDepartment of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)
  • Björling, Gunilla,DocentKarolinska Institutet,Sophiahemmet Högskola,Division of Anaesthesia and Intensive Care, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm(Swepub:rkh)bjog (författare)
  • Karlsson, SigbrittKTH,Fiber- och polymerteknologi,Fibre and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, Stockholm(Swepub:kth)u1g9umtq (författare)
  • Shah, PallavDepartment of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)
  • Goldstraw, PeterDepartment of Thoracic Surgery, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)
  • Moxham, JohnDepartment of Respiratory Medicine, Kings College Hospital, London, United Kingdom (författare)
  • Jordan, SimonDepartment of Thoracic Surgery, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)
  • Polkey, Michael I.Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United Kingdom (författare)
  • Department of Respiratory Medicine, Royal Brompton and Harefield NHS Trust, London, United KingdomDepartment of Thoracic Surgery, Royal Brompton and Harefield NHS Trust, London, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Annals of Thoracic Surgery: Elsevier BV89:3, s. 899-906E20003-49751552-6259

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