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Sökning: onr:"swepub:oai:DiVA.org:kth-227355" > Combined ASRGL1 and...

  • Huvila, J.Univ Turku, Turku Univ Hosp, Dept Pathol, Pl 52, FIN-20520 Turku, Finland,Turun Yliopisto,University of Turku (författare)

Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • Academic Press Inc.2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:kth-227355
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-227355URI
  • https://doi.org/10.1016/j.ygyno.2018.02.016DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-352701URI
  • https://research.chalmers.se/publication/501768URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Export Date: 9 May 2018; Article; CODEN: GYNOA; Correspondence Address: Huvila, J.; Department of Pathology, University of Turku, Kiinamyllynkatu 8-10, Finland; email: jutta.huvila@utu.fi; Funding details: 16X064, NCI, National Cancer Institute; Funding details: UH, University Hospitals; Funding details: Swedish Cancer Foundation; Funding details: HMRF, Health and Medical Research Fund; Funding details: Knut och Alice Wallenbergs Stiftelse; Funding details: 272437, Academy of Finland; Funding details: 295504, Academy of Finland; Funding details: 269862, Academy of Finland; Funding details: 292611, Academy of Finland; Funding details: 279163, Academy of Finland; Funding details: 85121904; Funding details: Syöpäjärjestöt; Funding details: TA, Tennis Australia; Funding details: Evonik Stiftung; Funding details: PHE, Public Health England; Funding details: FPInnovations; Funding text: This work was supported by University of Turku Doctoral Program of Clinical Investigations, Regional Fund of Finland Proper of the Finnish Cultural Foundation (grant 85121904 ), Medical Research Fund (EVO) of Turku University Hospital [JH]; Academy of Finland (grants 292611 , 269862 , 272437 , 279163 , 295504 ), National Cancer Institute ( 16X064 ), Cancer Society of Finland [TA] and by grants from the Knut and Alice Wallenberg Foundation (FP, AM, PHE) and the Swedish Cancer foundation (FP). QC 20180604
  • Objective: In clinical practise, prognostication of endometrial cancer is based on clinicopathological risk factors. The use of immunohistochemistry-based markers as prognostic tools is generally not recommended and a systematic analysis of their utility as a panel is lacking. We evaluated whether an immunohistochemical marker panel could reliably assess endometrioid endometrial cancer (EEC) outcome independent of clinicopathological information. Methods: A cohort of 306 EEC specimens was profiled using tissue microarray (TMA). Cost- and time-efficient immunohistochemical analysis of well-established tissue biomarkers (ER, PR, HER2, Ki-67, MLH1 and p53) and two new biomarkers (L1CAM and ASRGL1) was carried out. Statistical modelling with embedded variable selection was applied on the staining results to identify minimal prognostic panels with maximal prognostic accuracy without compromising generalizability. Results: A panel including p53 and ASRGL1 immunohistochemistry was identified as the most accurate predictor of relapse-free and disease-specific survival. Within this panel, patients were allocated into high- (5.9%), intermediate- (29.5%) and low- (64.6%) risk groups where high-risk patients had a 30-fold risk (P < 0.001) of dying of EEC compared to the low-risk group. Conclusions: P53 and ASRGL1 immunoprofiling stratifies EEC patients into three risk groups with significantly different outcomes. This simple and easily applicable panel could provide a useful tool in EEC risk stratification and guiding the allocation of treatment modalities. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Laajala, T. D.Univ Turku, Dept Math & Stat, Pl20, Helsinki 00014, Finland;Univ Helsinki, FIMM, Inst Mol Med Finland, Pl20, FIN-00014 Helsinki, Finland,Helsingin Yliopisto,University of Helsinki,Turun Yliopisto,University of Turku (författare)
  • Edqvist, Per-Henrik DUppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab,Uppsala University(Swepub:uu)peedq227 (författare)
  • Mardinoglu, AdilKTH,Science for Life Laboratory, SciLifeLab,Department of Biology and Biological Engineering, Chalmers University of Technology, 41296 Gothenburg, Sweden,KTH Royal Inst Technol, Sci Life Lab, S-10044 Stockholm, Sweden;Chalmers Univ Technol, Dept Biol & Biol Engn, S-41296 Gothenburg, Sweden,Chalmers tekniska högskola,Chalmers University of Technology,Kungliga Tekniska Högskolan (KTH),Royal Institute of Technology (KTH)(Swepub:cth)adilm (författare)
  • Talve, L.Univ Turku, Turku Univ Hosp, Dept Pathol, Pl 52, FIN-20520 Turku, Finland,Turun Yliopisto,University of Turku (författare)
  • Pontén, FredrikUppsala universitet,Klinisk och experimentell patologi,Science for Life Laboratory, SciLifeLab,Uppsala University(Swepub:uu)fredpont (författare)
  • Grénman, S.Univ Turku, Turku Univ Hosp, Dept Gynaecol & Obstet, Pl52, FIN-20520 Turku, Finland,Turun Yliopisto,University of Turku (författare)
  • Carpén, O.Univ Turku, Turku Univ Hosp, Dept Pathol, Pl 52, FIN-20520 Turku, Finland;Univ Helsinki, Dept Pathol, Helsinki, Finland;Finland HUSIAB, Pl720, Helsinki 00029, Finland,Helsingin Yliopisto,University of Helsinki,Turun Yliopisto,University of Turku (författare)
  • Aittokallio, T.Univ Turku, Dept Math & Stat, Pl20, Helsinki 00014, Finland;Univ Helsinki, FIMM, Inst Mol Med Finland, Pl20, FIN-00014 Helsinki, Finland,Turun Yliopisto,University of Turku,Helsingin Yliopisto,University of Helsinki (författare)
  • Auranen, A.Univ Tampere, Tampere Univ Hosp, Dept Gynaecol & Obstet, Pl2000, Tampere 33521, Finland,Tampereen Yliopisto,University of Tampere (författare)
  • Univ Turku, Turku Univ Hosp, Dept Pathol, Pl 52, FIN-20520 Turku, FinlandTurun Yliopisto (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Gynecologic Oncology: Academic Press Inc.149:1, s. 173-1800090-82581095-6859

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